Text Size:AAA

 Leukemia Inhibitory Factor/LIF  基因

All LIF Reagents

Leukemia Inhibitory Factor/LIF

Browse Leukemia Inhibitory Factor/LIF Products by

Leukemia Inhibitory Factor/LIF 相关研究领域

Leukemia Inhibitory Factor/LIF 相关信号通路

    Leukemia Inhibitory Factor/LIF 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Leukemia Inhibitory Factor/LIF 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Featured Reagent Products

    Leukemia Inhibitory Factor/LIF 概述&蛋白信息

    Leukemia Inhibitory Factor/LIF 相关资讯

    Leukemia Inhibitory Factor/LIF 研究背景

    基因概述: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
    General information above from NCBI
    亚细胞定位: Secreted.
    相似的序列: Belongs to the LIF/OSM family. {ECO:0000305}.
    General information above from UniProt

    Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

    Leukemia Inhibitory Factor/LIF 别称

    Leukemia Inhibitory Factor,CDF,DIA,HILDA,MLPLI, []
    CDF,DIA,HILDA,MLPLI, [homo-sapiens]
    d factor,OTTMUSP00000005253,RP23-329P17.1, [human]

    Leukemia Inhibitory Factor/LIF 相关文献

  • Salas EM, et al. (2011) LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer. 2 (5): 593-6.
  • Chodorowska G, et al. (2004) Leukemia inhibitory factor (LIF) and its biological activity. Ann Univ Mariae Curie Sklodowska Med. 59 (2): 189-93.
  • Garcia-Campana AM, et al. (2007) LIF detection of peptides and proteins in CE. Electrophoresis. 28 (1-2): 208-32.
  • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”