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 PD-L1/B7-H1/CD274  抗体

All CD274 Reagents

PD-L1/B7-H1/CD274
反应性: Human  
应用 : ELISA  
10084-RP02-50
10084-RP02-100
50 µg 
100 µg 
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    反应性: Human  
    应用 : ELISA  
    10084-MM31-50
    10084-MM31-200
    10084-MM31-100
    50 µg 
    200 µg 
    100 µg 
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      反应性: Human  
      应用 : ELISA  
      10084-MM13-50
      10084-MM13-100
      50 µg 
      100 µg 
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        反应性: Human  
        应用 : ELISA  
        10084-R001-50
        10084-R001-100
        50 µg 
        100 µg 
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          反应性: Human  
          应用 : ELISA  IHC-P  
          10084-T24-50
          10084-T24-200
          10084-T24-100
          50 µg 
          200 µg 
          100 µg 
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          反应性: Human  
          应用 : B/N  
          10084-R639-500
          10084-R639-200
          500 µg 
          200 µg 
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            反应性: Human  
            应用 : ELISA  IHC-P  
            10084-R015-50
            10084-R015-100
            50 µg 
            100 µg 
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            • Slide 1
            反应性: Human  
            应用 : ELISA  
            10084-RP01-200
            10084-RP01-100
            200 µg 
            100 µg 
            Add to Cart
              反应性: Human  
              应用 : ELISA  
              10084-MM02-50
              10084-MM02-200
              10084-MM02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
                反应性: Human  
                应用 : IHC-P  
                10084-MB55-50
                10084-MB55-200
                10084-MB55-100
                50 µg 
                200 µg 
                100 µg 
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                • Slide 1
                • Slide 1
                • Slide 1
                反应性: Human  
                应用 : ELISA  
                10084-T16-50
                10084-T16-100
                50 µg 
                100 µg 
                Add to Cart
                  10084-H02HL-300 
                  10084-H08HL-300 

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                  PD-L1/B7-H1/CD274 相关研究领域

                  PD-L1/B7-H1/CD274 相关信号通路

                    PD-L1/B7-H1/CD274 相关蛋白、抗体、cDNA基因、ELISA试剂盒

                    PD-L1/B7-H1/CD274 相关蛋白、抗体、cDNA基因、ELISA试剂盒

                    Featured Reagent Products

                    PD-L1/B7-H1/CD274 概述&蛋白信息

                    PD-L1/B7-H1/CD274 研究背景

                    亚单位结构: Interacts with PDCD1.
                    亚细胞定位: Isoform 1: Cell membrane; Single-pass type I membrane protein.
                    Isoform 2: Endomembrane system; Single-pass type I membrane protein.
                    组织特异性: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
                    诱导: Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up- regulated in B-cells activated by surface Ig cross-linking.
                    相似的序列: Belongs to the immunoglobulin superfamily. BTN/MOG family.
                    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
                    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
                    General information above from UniProt

                    Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

                    Immune Checkpoint
                    Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD-L1 / B7-H1 / CD274 Blocking Antibodies
                    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
                    Immune Checkpoint Proteins   PD-L1 / B7-H1 / CD274 Immune Checkpoint Proteins
                    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

                    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                    PD-L1/B7-H1/CD274 别称

                    PD-L1/B7-H1/CD274 相关文献

                  • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
                  • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
                  • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
                  • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
                  • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.
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