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 STK10/LOK  抗体

All STK10 Reagents

STK10/LOK
反应性: Human  
应用 : ELISA  
11724-RP01-400
11724-RP01-200
11724-RP01-100
400 µg 
200 µg 
100 µg 
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    反应性: Human  
    应用 : ELISA  
    11724-RP02-50
    11724-RP02-200
    11724-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart

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      STK10/LOK 相关研究领域

      STK10/LOK 相关信号通路

        STK10/LOK 相关蛋白、抗体、cDNA基因、ELISA试剂盒

        STK10/LOK 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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        STK10/LOK 概述&蛋白信息

        STK10/LOK 研究背景

        基因概述: STK10 gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
        General information above from NCBI
        催化活性: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:18239682}.
        酶调控: ENZYME REGULATION: Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib. {ECO:0000269|PubMed:18239682, ECO:0000269|PubMed:21606217}.
        亚单位结构: Homodimer; homodimerization is required for activation segment autophosphorylation. {ECO:0000269|PubMed:18239682}.
        亚细胞定位: Cell membrane {ECO:0000269|PubMed:19255442}; Peripheral membrane protein {ECO:0000269|PubMed:19255442}.
        组织特异性: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. {ECO:0000269|PubMed:12639966}.
        翻译后修饰: Autophosphorylates following homodimerization, leading to activation of the protein.
        相关疾病 : DISEASE: Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. {ECO:0000269|PubMed:16175573}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
        相似的序列: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
        General information above from UniProt

        Serine / threonine-protein kinase 10, also known as Lymphocyte-oriented kinase, STK10 and LOK, which belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE20 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK10 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK10 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk10 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.

        STK10/LOK 别称

        LOK,PRO2729, [homo-sapiens]
        LOK,PRO2729,STK10, [human]
        Gek1,KIAA4026,Lok,mKIAA4026,RP23-395O6.3,Stk10, [mouse]
        Lok,Gek1,mKIAA4026, [mus-musculus]

        STK10/LOK 相关文献

      • Kuramochi S, et al., 1997, J. Biol. Chem. 272 (36): 22679-84.
      • Kuramochi S, et al., 1999, Immunogenetics. 49 (5): 369-75. 
      • Walter, SA. et al., J Biol Chem 2003, 278 (20):18221-8.
      • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”