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 VEGF/VEGFA  抗体

All VEGF Reagents

VEGF/VEGFA
反应性: Human  
应用 : ELISA  
    11066-T16-50
    11066-T16-200
    11066-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10008-RP01-400
      10008-RP01-200
      10008-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  WB  IHC-P  
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      10009-RP02-50
      10009-RP02-200
      10009-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : B/N  
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      11066-R010-500
      11066-R010-200
      500 µg 
      200 µg 
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      反应性: Human  
      应用 : 
        10008-R145-50
        10008-R145-100
        10008-R145-1
        50 µg 
        100 µg 
        1 mg 
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        反应性: Human  
        应用 : ELISA  
          10008-R064-50
          10008-R064-100
          10008-R064-1
          50 µg 
          100 µg 
          1 mg 
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          反应性: Human  
          应用 : ELISA  
            11066-RP01-400
            11066-RP01-200
            11066-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Human  
            应用 : ELISA  
              11066-RP02-50
              11066-RP02-200
              11066-RP02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Human  
              应用 : WB  IP  
              • Slide 1
              • Slide 1
              100253-T36-50
              100253-T36-200
              100253-T36-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Human  
              应用 : ELISA  
                11066-R105-50
                11066-R105-100
                50 µg 
                100 µg 
                Add to Cart
                反应性: Human  
                应用 : ELISA  
                  10009-RP01-400
                  10009-RP01-200
                  10009-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反应性: Human  
                  应用 : ELISA  
                    10008-RP02-50
                    10008-RP02-200
                    10008-RP02-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    反应性: Human  
                    应用 : B/N  
                    • Slide 1
                    11066-R012-500
                    11066-R012-200
                    500 µg 
                    200 µg 
                    Add to Cart
                    10008-HNAHL-300 
                    11066-HNAHL-300 
                    15692-HNAHL-300 
                    11066-HNABL-300 
                    10008-HNABL-300 

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                    VEGF/VEGFA 相关研究领域

                    VEGF/VEGFA 相关信号通路

                    VEGF/VEGFA 相关蛋白、抗体、cDNA基因、ELISA试剂盒

                    VEGF/VEGFA 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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                    VEGF/VEGFA 概述&蛋白信息

                    VEGF/VEGFA 相关资讯

                    VEGF/VEGFA 研究背景

                    亚单位结构: Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). {ECO:0000250}.
                    亚细胞定位: Secreted {ECO:0000269|PubMed:11563986, ECO:0000269|PubMed:11731620, ECO:0000269|PubMed:15896327}. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
                    组织特异性: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:22009797}.
                    诱导: By hypoxia. Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoglycemia and oncogenic mutations. {ECO:0000269|PubMed:22009797}.
                    相关疾病 : DISEASE: Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
                    相似的序列: Belongs to the PDGF/VEGF growth factor family. {ECO:0000305}.
                    General information above from UniProt

                    Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.

                    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                    VEGF/VEGFA 别称

                    VEGF/VEGFA 相关文献

                  • Woolard J. et al. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64(21): 7822-7835.
                  • Jia SF, et al. (2008) VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. J Exp Ther Oncol. 7(2): 89-97.
                  • Cimpean AM, et al. (2008) Vascular endothelial growth factor A (VEGF A) as individual prognostic factor in invasive breast carcinoma. Rom J Morphol Embryol. 49(3): 303-8.
                  • Hamdollah Zadeh MA, et al. (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation. 15(7): 605-14.
                  • Eisenach PA, et al. (2010) MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 123(Pt 23):4182-4193.
                  • Claesson-Welsh L (2010) Gremlin: vexing VEGF receptor agonist. Blood. 116(18):3386-7.
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