PD-1 cDNA ORF Clone, Human, untagged

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PD-1 cDNA ORF Clone, Human, untagged: 产品信息

基因
种属
Human
NCBI 参考序列号
基因长度
867 bp
序列特征
Identical with the Gene Bank Ref. ID sequence.
产品特征
Full length Clone DNA of Human programmed cell death 1 (PDCD1).
质粒
启动子
Enhanced CMV promoter
限制性酶切位点
HindIII + XbaI (6.1kb + 0.87kb)
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Ampicillin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

PD-1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

PD-1 cDNA ORF Clone, Human, untagged: 别称

CD279 cDNA ORF Clone, Human; hPD-1 cDNA ORF Clone, Human; hPD-l cDNA ORF Clone, Human; hSLE1 cDNA ORF Clone, Human; PD-1 cDNA ORF Clone, Human; PD1 cDNA ORF Clone, Human; SLEB2 cDNA ORF Clone, Human

PD-1 背景信息

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-1 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
全称
programmed cell death 1
参考文献
  • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
  • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
  • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
  • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
  • Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients
    Author
    Osa, A;Uenami, T;Koyama, S;Fujimoto, K;Okuzaki, D;Takimoto, T;Hirata, H;Yano, Y;Yokota, S;Kinehara, Y;Naito, Y;Otsuka, T;Kanazu, M;Kuroyama, M;Hamaguchi, M;Koba, T;Futami, Y;Ishijima, M;Suga, Y;Akazawa, Y;Machiyama, H;Iwahori, K;Takamatsu, H;Nagatomo, I;Takeda, Y;Kida, H;Akbay, EA;Hammerman, PS;Wong, KK;Dranoff, G;Mori, M;Kijima, T;Kumanogoh, A;
    Year
    2018
    Journal
    JCI Insight
    Application
    expression
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