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IgA antibodies are quite different from IgG antibodies. IgA Antibody has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). In its secretory form, IgA is the main immunoglobulin found in mucous secretions, including tears, saliva, sweat, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in blood.
The dimeric IgA antibody can be produced using recombinant technology. By co-transfecting HEK293 cells with IgA antibody's light chain and heavy chain vectors, monomeric IgA antibodies can be expressed, but homo-dimer IgA antibody formation usually needs co-expression of the J-chain protein, which links the two IgA molecules together.
Sino Biological has accumulated hands-on experience in expression and producing the dimeric form of the IgA antibodies using our cutting-edge transient transfection platform. Our powerful transient transfection platform can offer great services to customers worldwide.
How to Submit a Request for Antibody Production and Purification Service?
If you are interested in using our antibody purification services to support your antibody discovery and development program, please contact us by leaving an on-line message or send us your detailed request to CROfirstname.lastname@example.org. Based on the quantity and quality requirement of your request, a formal quote will be send back to you for your review, comment, and/or acceptance.