IL-12 Family Ligand

Each IL-12 family member is composed of alpha-subunit with a helical structure similar to type 1 cytokines like IL-6 and a beta-subunit structurally related to the extracellular regions of Type 1 cytokine receptors (e.g. soluble IL-6 receptor).
IL-12 family cytokines are important mediators of immune-mediated inflammatory diseases such as psoriasis, multiple sclerosis, rheumatoid arthritis, and Crohn's disease.

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IL-12 Family Ligand Table

Type I cytokines include the IL-6 and IL-12 families, which consist of structurally related four-helix bundle proteins. Unlike members of the IL-6 family, which are secreted as single-subunit monomers, IL-12 family members form heterodimeric complexes.

Ligand Subunits Receptor Function
IL-12 p35+p40 IL12RB1(CD212), IL12RB2 Th1 differentiation; Th2 inhibition
IL-23 p19+p40 IL12RB1(CD212), IL23R / IL23 Receptor Th17 differentiation
IL-27 p28+EBI3 IL12RB1(CD212), WSX-1/IL-27R Th1 differentiation Suppression of Th17;
differentiation Stimulation of Tr1 cells
IL-35 p35+EBI3 IL12RB2, IL6ST/gp130/CD130, WSX-1/IL-27R Treg proliferation Suppression of Th1 and Th17
cell development

IL-12 Family Ligand Review

The IL-12 family of cytokines consist of IL-12 (IL-12p35/IL-12p40), IL-23 (IL-23p19/IL-12p40), IL-27 (IL-27p28/Ebi3) and IL-35 (IL-12p35/Ebi3) and has emerged as important regulators of host immunity.

The following are outlines of "IL-12 Family Ligand Review Page", which briefly introduce each member of IL-12 family ligand. If you want more details, please click here.

• IL-12 Receptor • IL-27 Receptor
• IL-23 Receptor • IL-35 Receptor