Each IL-12 family member is composed of alpha-subunit with a helical structure similar to type 1 cytokines like IL-6 and a beta-subunit structurally related to the extracellular regions of Type 1 cytokine receptors (e.g. soluble IL-6 receptor).
IL-12 family cytokines are important mediators of immune-mediated inflammatory diseases such as psoriasis, multiple sclerosis, rheumatoid arthritis, and Crohn's disease.
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Type I cytokines include the IL-6 and IL-12 families, which consist of structurally related four-helix bundle proteins. Unlike members of the IL-6 family, which are secreted as single-subunit monomers, IL-12 family members form heterodimeric complexes.
|IL-12||p35+p40||IL12RB1(CD212), IL12RB2||Th1 differentiation; Th2 inhibition|
|IL-23||p19+p40||IL12RB1(CD212), IL23R / IL23 Receptor||Th17 differentiation|
|IL-27||p28+EBI3||IL12RB1(CD212), WSX-1/IL-27R||Th1 differentiation Suppression of Th17;
differentiation Stimulation of Tr1 cells
|IL-35||p35+EBI3||IL12RB2, IL6ST/gp130/CD130, WSX-1/IL-27R||Treg proliferation Suppression of Th1 and Th17
The IL-12 family of cytokines consist of IL-12 (IL-12p35/IL-12p40), IL-23 (IL-23p19/IL-12p40), IL-27 (IL-27p28/Ebi3) and IL-35 (IL-12p35/Ebi3) and has emerged as important regulators of host immunity.
The following are outlines of "IL-12 Family Ligand Review Page", which briefly introduce each member of IL-12 family ligand. If you want more details, please click here.
|• IL-12 Receptor||• IL-27 Receptor|
|• IL-23 Receptor||• IL-35 Receptor|