流感病毒科研试剂:重组蛋白,抗体,基因,试剂盒

流感病毒主要感染哺乳动物类以及鸟类,并引起呼吸道疾病。流感病毒是一种RNA病毒,属于正黏病毒科。这种病毒有三个类型,通常称作甲型(A)流感,乙型(B)流感和丙型(C)流感。依据HA蛋白和NA蛋白的不同,同种类型的流感病毒又可以分为不同的亚型。甲型流感在动物以及鸟类中广泛分布,能造成流感大流行。乙型流感主要在人和海豹中感染,引起流感局部爆发。丙型流感几乎不引起疾病。

雄厚的研发和生产实力

• 所有产品均是自主研发
• 12天— H7N9病毒抗原蛋白快速研发
• 6个月— H7N9临床前中和抗体快速研发

产品覆盖多数亚型以及毒株

• 2500+ 科研试剂: 重组蛋白,抗体,基因,ELISA 试剂盒
• 60多种亚型: H1-H18, N1-N11, Influenza B
• 250多种毒株: 疫苗株, HPAI 株, 重点株, 新毒株
• 十种流感病毒抗原分子: HA (HA0, HA1, HA2, HA), NA, NP, M1, M2, NS1, NS2, PB1, PB2, PA

广泛的应用

• 基础研究
• 抗病毒药物研究
• 病毒疫苗开发
• 病毒检测
• 抗病毒抗体研发

流感病毒蛋白

流感病毒血凝素蛋白 (hemagglutinin)

全长血凝素蛋白

Full length HA protein is always the first choice of antigen for vaccine development. Because of transmembrane domain, it has been very diffcult to manufacture. That is why you can hardly buy HA0. Here is part of full length HA protein produced by Sino Biological Inc. We also can provide CRO service for you.

货号 抗原分子 亚型 毒株
11055-VNAB full length hemagglutinin H1N1 A/California/04/2009
40043-VNAB full length hemagglutinin H3N2 A/Perth/16/2009
40153-VNAB full length hemagglutinin H3N2 A/Babol/36/2005
40497-VNAB full length hemagglutinin H3N2 A/Switzerland/9715293/2013
40359-VNAB full length hemagglutinin H10N8 A/Jiangxi-Donghu/346/2013
40191-VNAB full length hemagglutinin Influenza B B/Massachusetts/03/2010
40498-VNAB full length hemagglutinin Influenza B B/PHUKET/3073/2013

HA-B细胞特异性探针蛋白 (HA-specific B cell probe)

The antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines. Flu vaccines stimulate B cells in the blood to produce antibodies that neutralize the virus. Mutation (Y98F) to the receptor binding site (RBS) causes HA to bind only those B cells that express HA-specific Abs.

货号 抗原分子 亚型 毒株
11055-V08B1 HA-specific B cell probe H1N1 A/California/4/2009
11683-V08B1 HA-specific B cell probe H1N1 A/New Caledonia/20/99
40043-V08B1 HA-specific B cell probe H3N2 A/Perth/16/2009
11060-V08B1 HA-specific B cell probe H5N1 A/Indonesia/5/2005

高血凝活性

1%RBC的HA 滴度值低至 0.2-0.8 ng/mL

高结合活性

结合Neu5Aca2-6GalNAca-PAA-biotin 或者Neu5Aca2-3Galb1-4GlcNAcb-PAA-biotin

中和抗体靶点

流感病毒神经氨酸酶(neuraminidase)蛋白

高酶切活性

活性检测方法:分解荧光底物2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid。活性值高达 3000pmol/min/ug.

货号 抗原分子 亚型 毒株
40196-VNAHC Neuraminidase / NA (Active) H1N1 A/Puerto Rico/8/1934
40235-VNAHC Neuraminidase / NA (Active) H4N6 A/mallard/Ohio/657/2002
40045-VNAHC Neuraminidase / NA (Active) H5N1 A/Egypt/2321-NAMRU3/2007
40202-VNAHC Neuraminidase / NA (Active) H7N7 A/Netherlands/219/03
40108-VNAHC Neuraminidase / NA (Active) H7N9 A/Anhui/1/2013
40109-VNAHC Neuraminidase / NA (Active) H7N9 A/Shanghai/1/2013
40034-VNAHC Neuraminidase / NA (Active) H9N2 A/Chicken/Hong Kong/G9/97

NA突变体蛋白:抗药性

某些毒株的NA发生突变后,对抗流感药物达菲、扎那米韦、帕拉米韦等具有体抗力;是新型抗流感药物的筛选靶点。

货号 亚型 突变位点 酶活
11058-VNAHC1 H1N1 H274Y mutation Active
11058-VNAHC2 H1N1 N295S mutation Active
11676-VNAHC1 H5N1 H274Y mutation Active
40017-VNAHC1 H3N2 E119V mutation Active
40017-VNAHC2 H3N2 N294S mutation Active
40017-VNAHC3 H3N2 R292K mutation Active
40017-VNAHC4 H3N2 H274Y mutation Active

流感病毒抗体

中和抗体

抗体HA中和抗体, H1, H3, H5, H7, H10

H10N8 A/Jiangxi-Donghu/346/2013 pseudovirus infection in 293FT cells. The inhibition is 99.3% under 1 µg/mL antibody (40359-mh001).

血凝抑制抗体

货号: 11082-R002
抑制1 unit H7N9 HA蛋白(40105-V08B)血凝活性的最低抗体浓度值低至0.16 μg/mL

广谱结合抗体

抗流感HA蛋白 : 86001-RM01
• 与80多株毒株的HA蛋白均有交叉反应
• 与H1-H16 HA 均有结合
抗流感NP蛋白多抗: 11675-RP01, 11675-RP02
• 广谱结合同类型流感NP蛋白
• 高灵敏度

流感病毒ELISA试剂盒

高灵敏度

可检测的HA 浓度低至3 pg/mL

高稳定度

单抗-单抗组合的捕获抗体以及检测抗体对,稳定性更好

类型 货号 亚型 抗原分子 捕获抗体 检测抗体
ELISA kit KIT11684 H1N1 HA mouse monoclonal antibody mouse monoclonal antibody
ELISA kit KIT11055 H1N1 HA mouse monoclonal antibody rabbit polyclonal antibody
ELISA kit KIT11056 H3N2 HA rabbit monoclonal antibody mouse monoclonal antibody
ELISA kit KIT11714 H4N6 HA mouse monoclonal antibody mouse monoclonal antibody
ELISA kit KIT40103 H7N9 HA rabbit monoclonal antibody rabbit polyclonal antibody
ELISA kit KIT40104 H7N9 HA rabbit monoclonal antibody rabbit polyclonal antibody
pair set SEK11684 H1N1 HA monoclonal antibody monoclonal antibody
pair set SEKA11684 H1N1 HA monoclonal antibody monoclonal antibody
pair set SEK001 H1N1 HA monoclonal antibody polyclonal antibody
pair set SEK11056 H3N2 HA monoclonal antibody monoclonal antibody
pair set SEK11714 H4N6 HA monoclonal antibody monoclonal antibody
pair set SEK002 H5N1 HA monoclonal antibody polyclonal antibody
pair set SEK11082 H7N7 HA monoclonal antibody polyclonal antibody
pair set SEK40103 H7N9 HA monoclonal antibody polyclonal antibody
pair set SEK40104 H7N9 HA monoclonal antibody polyclonal antibody
pair set SEK11229 H9N2 HA monoclonal antibody polyclonal antibody
pair set SEK11053 Influenza B HA monoclonal antibody polyclonal antibody

按分子查询流感病毒试剂