Anti-NKp46/NCR1 Magnetic Beads Immunoprecipitation (IP) Kit

Temporarily not available outside of China.

Anti-NKp46/NCR1 磁珠免疫沉淀(IP)试剂盒产品组分

Components Storage
Anti-NKp46/NCR1 Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-NKp46/NCR1 magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

Anti-NKp46/NCR1 磁珠免疫沉淀(IP)试剂盒产品描述

The Anti-NKp46/NCR1 magnetic Beads, conjugated with Anti-NKp46/NCR1 antibody, are used for immuneprecipitation (IP) of NKp46/NCR1 proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing NKp46/NCR1 proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound NKp46/NCR1 proteins are dissociated from the magnetic beads using an elution buffer.

Anti-NKp46/NCR1 磁珠免疫沉淀(IP)试剂盒抗体信息

Anti-NKp46/NCR1 Antibody, Rabbit Polyclonal(310305-T36)
E. coli-derived Human NKp46 fragment
Human NKp46
Polyclonal Human Rabbit IgG
Produced in rabbits immunized with E. coli-derived Human NKp46 fragment, and purified by antigen affinity chromatography.
Immunoprecipitation (IP), Minimum Protein Purification

Anti-NKp46/NCR1 Magnetic Beads Immunoprecipitation (IP) Kit: 别称

Anti-CD335ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-LY94ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-NK-p46ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-NKP46ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

NKp46/NCR1 背景信息

NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines, and mononuclear phagocytes infected with an intracellular bacterium.
natural cytotoxicity triggering receptor 1
  • Carbone E, et al. (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood. 105(1):251-8.
  • Sivori S, et al. (1997) p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation. J Exp Med. 186(7):1129-36.
  • Biassoni R, et al. (2004) Human natural killer cell receptors: insights into their molecular function and structure. J Cell Mol Med. 7(4):376-87.
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