Low Endotoxin Antibody Purification Service Description

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Low Endotoxin Antibody Production & Purification Service Description

Endotoxin is a class of large molecules consisting of a lipid and a polysaccharide. The polysaccharide is composed of O-antigen, outer core and inner core joined by a covalent bond. Endotoxin is derived from the outer membrane of Gram-negative bacteria. Endotoxin can elicit strong immune responses in animals and human, and hence it is important to limit the amount of endotoxin contaminant in injectable protein and antibody products.

In production of monoclonal antibodies for pre-clinical animal studies, one would usually need to control the endotoxin level in the final product to avoid any size effects caused by endotoxin. Endotoxin is usually introduced into the culture systems through raw material, culture medium, container, and plasmids used for transfection. Because the DNA plasmid is produced from E. coli. fermentation, it usually contains very high level of endotoxin. Therefore, it is important to control the quality of raw materials and cell culture medium, and equally important to eliminate endotoxin from the DNA plasmid for transfection. After protein A affinity purification, the endotoxin level is usually still above the acceptable level, and hence typically one would need to use polishing chromatography steps to separate and remove endotoxin from the antibody product.

Sino Biological has produced hundreds of endotoxin controlled monoclonal antibodies for various animal studies for customers worldwide. Our endotoxin controlled antibody production service can meet antibody quality suitable for human use. Specifically, if required, the endotoxin level can be reduced to as low as 0.01-0.05 EU/mg.

How to Submit a Request for Antibody Purification Service?

If you are interested in using our antibody purification services to support your antibody discovery and development program, please contact us by leaving an on-line message or send us your detailed request to CRO-service@sinobiological.com. Based on the quantity and quality requirement of your request, a formal quote will be send back to you for your review, comment, and/or acceptance.

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Low Endotoxin Antibody Purification Service Description
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