LRRTM2 (Leucine-Rich Repeat Transmembrane Neuronal 2) is a Protein Coding gene. LRRTM2 belongs to the LRRTM family and is a key regulator of excitatory synapse development and function. It localizes to excitatory synapses in transfected hippocampal neurons, and shRNA-mediated knockdown of LRRTM2 leads to a decrease in excitatory synapses without affecting inhibitory synapses. LRRTM2 interacts with PSD-95 and regulates surface expression of AMPA receptors, and lentivirus-mediated knockdown of LRRTM2 in vivo decreases the strength of evoked excitatory synaptic currents. LRRTM2 induces only excitatory synapses, and that it also acts to induce synapses in transfected neurons similarly to neuroligin-1. Diseases associated with LRRTM2 include Tarp Syndrome and Histrionic Personality Disorder.
leucine rich repeat transmembrane neuronal 2