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MAP2K3/MKK3  蛋白,抗体,试剂盒,cDNA克隆

MAP2K3/MKK3 相关信号通路

MAP2K3/MKK3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

MAP2K3/MKK3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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MAP2K3/MKK3 概述&蛋白信息

MAP2K3/MKK3 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
酶调控: Activated by dual phosphorylation on Ser-218 and Thr-222.
亚单位结构: Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.
组织特异性: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
翻译后修饰: Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.
Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
相关疾病 : Note=Defects in MAP2K3 may be involved in colon cancer.
相似的序列: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.C
General information above from UniProt

MAP2K3/MKK3 别称

MEK3,MKK3,MAPKK3,PRKMK3,SAPKK2,SAPKK-2, [homo-sapiens]
MEK3,MKK3,Prkmk3,mMKK3b,AW212142, [mus-musculus]

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