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Antibody's complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) function is crucial for its anti-cancer efficacy. On the other hand, for some non-cancer treatments, antibody's CDC and ADCC function may not be desirable. So apparently, sometimes one would desire to increase an antibody's CDC and ADCC activities and some other times, one may prefer to eliminate or reduce an antibody's CDC and ADCC function. To achieve such a goal, one could modify the antibody's Fc region where the antibody interacts with and binds to Fc receptor proteins on human immune cells.
Sino Biological has developed a comprehensive set of techniques in house to engineer an antibody's Fc amino acids to increase or decrease its CDC and ADCC function, increase its binding to FcRn and increase its pharmacokinetics. The capability is further enhanced with our rapid and high-throughput antibody production by transient transfection and our comprehensive list of Fc receptor proteins. Our antibody Fc engineering service is fast, affordable, and reliable. Contact us now to learn more about our expertise and service on antibody Fc engineering.
How to Submit a Request for Antibody Humanization & Fc engineering Service?
If you are interested in using our antibody humanization and Fc engineering services to support your antibody discovery and development program, please contact us by leaving an on-line message or send us your detailed request to CROfirstname.lastname@example.org. Based on the quantity and quality requirement of your request, a formal quote will be send back to you for your review, comment, and/or acceptance.