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小鼠 ACVR2B/Activin RIIB  抗体

All ACVR2B  Reagents

ACVR2B/Activin RIIB
反应性: Mouse  
应用 : ELISA  
50173-R307-50
50173-R307-100
50 µg 
100 µg 
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    反应性: Mouse  
    应用 : ELISA  WB  
    50173-RP01-400
    50173-RP01-200
    50173-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    • Slide 1
    反应性: Mouse  
    应用 : ELISA  
    50173-RP02-50
    50173-RP02-200
    50173-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
      反应性: Mouse  
      应用 : ELISA  
      50173-R105-50
      50173-R105-100
      50 µg 
      100 µg 
      Add to Cart
        反应性: Human  
        应用 : ELISA  
        10229-R037-50
        10229-R037-100
        50 µg 
        100 µg 
        Add to Cart
          50173-M03HL-300 
          50173-M08HL-300 

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          ACVR2B/Activin RIIB 相关研究领域

          ACVR2B/Activin RIIB 相关信号通路

          ACVR2B/Activin RIIB 相关蛋白、抗体、cDNA基因、ELISA试剂盒

          ACVR2B/Activin RIIB 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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          ACVR2B/Activin RIIB 概述&蛋白信息

          ACVR2B/Activin RIIB 相关资讯

          ACVR2B/Activin RIIB 研究背景

          基因概述: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
          General information above from NCBI
          催化活性: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
          辅因子: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
          亚单位结构: Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. {ECO:0000269|PubMed:12941698, ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:8622651}.
          亚细胞定位: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
          翻译后修饰: Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity. {ECO:0000269|PubMed:8622651}.
          相关疾病 : DISEASE: Heterotaxy, visceral, 4, autosomal (HTX4) [MIM:613751]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. {ECO:0000269|PubMed:9916847}. Note=The disease is caused by mutations affecting the gene represented in this entry.
          相似的序列: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
          General information above from UniProt

          ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

          ACVR2B/Activin RIIB 别称

          4930516B21Rik,Activin RIIB,HTX4, []
          HTX4,ACTRIIB,ActR-IIB, [homo-sapiens]
          ACVR2B,ActR-IIB,MGC116908,ACTRIIB, [human]
          ActRIIB,Acvr2b,MGC118477, [mouse]
          ActRIIB, [mus-musculus]

          ACVR2B/Activin RIIB 相关文献

          1. Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
          2. Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
          3. Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
          4. Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
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