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小鼠 BAMBI/NMA  蛋白

All BAMBI Reagents

BAMBI/NMA
表达宿主: Human Cells  
50895-M08H-50
50895-M08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
50895-M02H-50
50895-M02H-20
50 µg 
20 µg 
Add to Cart
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BAMBI/NMA 相关研究领域

BAMBI/NMA 相关信号通路

BAMBI/NMA 相关蛋白、抗体、cDNA基因、ELISA试剂盒

BAMBI/NMA 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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BAMBI/NMA 概述&蛋白信息

BAMBI/NMA 相关资讯

BAMBI/NMA 研究背景

基因概述: BAMBI gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
General information above from NCBI
亚细胞定位: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
组织特异性: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
发育阶段: Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.
相似的序列: Belongs to the BAMBI family. {ECO:0000305}.
General information above from UniProt

BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

BAMBI/NMA 别称

BAMBI/NMA 相关文献

  • Sekiya T, et al. (2003) Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor- Signaling, as a Target of the -Catenin Pathway in Colorectal Tumor Cells. The Journal of Biological Chemistry. 279:6840-6.
  • Shi YG, et al. (2003) Mechanisms of TGF- Signaling from Cell Membrane to the Nucleus. Cell. 113(6): 685-700.
  • Wanninger J, et al. (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585(9):1338-44.
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