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小鼠 Cystatin 7 / CST7  抗体

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Cystatin 7 / CST7
反应性: Mouse  
应用 : ELISA  
50 µg 
200 µg 
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    反应性: Mouse  
    应用 : ELISA  
    400 µg 
    200 µg 
    100 µg 
    Add to Cart

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      Cystatin 7 / CST7 相关研究领域

      Cystatin 7 / CST7 相关信号通路

        Cystatin 7 / CST7 相关蛋白、抗体、cDNA基因、ELISA试剂盒

        Cystatin 7 / CST7 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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        Cystatin 7 / CST7 概述&蛋白信息

        Cystatin 7 / CST7 研究背景

        基因概述: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors.
        General information above from NCBI
        亚单位结构: Homodimer; disulfide-linked. {ECO:0000269|PubMed:16601115}.
        亚细胞定位: Secreted {ECO:0000269|PubMed:12423348}. Cytoplasm {ECO:0000269|PubMed:12423348}.
        组织特异性: Primarily expressed in peripheral blood cells and spleen.
        相似的序列: Belongs to the cystatin family. {ECO:0000305}.
        General information above from UniProt

        The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.

        Cystatin 7 / CST7 别称

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