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小鼠 Leukotriene A4 Hydrolase/LTA4H  抗体

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Leukotriene A4 Hydrolase/LTA4H
反应性: Mouse  
应用 : ELISA  
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    反应性: Mouse  
    应用 : ELISA  WB  IP  
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    Leukotriene A4 Hydrolase/LTA4H 相关研究领域

    Leukotriene A4 Hydrolase/LTA4H 相关信号通路

      Leukotriene A4 Hydrolase/LTA4H 相关蛋白、抗体、cDNA基因、ELISA试剂盒

      Leukotriene A4 Hydrolase/LTA4H 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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      Leukotriene A4 Hydrolase/LTA4H 概述&蛋白信息

      Leukotriene A4 Hydrolase/LTA4H 研究背景

      催化活性: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:7667299}.
      辅因子: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029};
      酶调控: ENZYME REGULATION: Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. {ECO:0000269|PubMed:7667299}.
      亚单位结构: Monomer. {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870}.
      亚细胞定位: Cytoplasm.
      组织特异性: Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
      翻译后修饰: Phosphorylation at Ser-416 inhibits enzymatic activity. {ECO:0000269|PubMed:9395533}.
      相似的序列: Belongs to the peptidase M1 family. {ECO:0000305}.
      General information above from UniProt

      Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

      Leukotriene A4 Hydrolase/LTA4H 别称

      LAT4, [Human]
      Leukotriene A4 Hydrolase,LTA4 hydrodase,Lta4h, [mouse]

      Leukotriene A4 Hydrolase/LTA4H 相关文献

    • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
    • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
    • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
    • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
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