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小鼠 Prostasin/PRSS8  抗体

All PRSS8 Reagents

Prostasin/PRSS8
反应性: Mouse  
应用 : ELISA  WB  IHC-P  
50120-T56-50
50120-T56-200
50120-T56-100
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50120-M08BL-300 

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Prostasin/PRSS8 相关研究领域

Prostasin/PRSS8 相关信号通路

    Prostasin/PRSS8 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Prostasin/PRSS8 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    Prostasin/PRSS8 概述&蛋白信息

    Prostasin/PRSS8 研究背景

    基因概述: PRSS8 gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亚单位结构: Heterodimer of two chains, light and heavy, held by a disulfide bond. {ECO:0000269|PubMed:19388054}.
    亚细胞定位: Prostasin: Cell membrane; Single-pass membrane protein.; Prostasin light chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.; Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.
    组织特异性: Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.
    相似的序列: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-ProRule:PRU00274}.; Contains 1 peptidase S1 domain. {ECO:0000255|PROSITE-ProRule:PRU00274}.
    General information above from UniProt

    Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

    Prostasin/PRSS8 别称

    Prostasin/PRSS8 相关文献

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