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小鼠 SerpinB10  抗体

All SerpinB10 Reagents

反应性: Mouse  
应用 : ELISA  
50 µg 
200 µg 
100 µg 
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    反应性: Mouse  
    应用 : ELISA  
    400 µg 
    200 µg 
    100 µg 
    Add to Cart

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      SerpinB10 相关研究领域

      SerpinB10 相关信号通路

        SerpinB10 相关蛋白、抗体、cDNA基因、ELISA试剂盒

        SerpinB10 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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        SerpinB10 概述&蛋白信息

        SerpinB10 研究背景

        基因概述: The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 , is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]
        General information above from NCBI
        亚细胞定位: Nucleus. Cytoplasm. Note=Mostly found in the nucleus.
        组织特异性: Expressed specifically in myeloid cells and the bone marrow. {ECO:0000269|PubMed:20433722, ECO:0000269|PubMed:7592909}.
        相似的序列: Belongs to the serpin family. Ov-serpin subfamily. {ECO:0000305}.
        General information above from UniProt

        Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified.
        Mouse SerpinB10, also known as Peptidase inhibitor 10, PI-10, Bomapin and SERPINB10, is a nucleus and cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB10 is expressed specifically in the bone marrow. SerpinB10 is a protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. SerpinB10 is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability. SerpinB10 may regulate protease activities in the cytoplasm and in the nucleus.

        SerpinB10 别称

        PI10,PI-10, [homo-sapiens]
        bomapin,PI10,PI-10,SerpinB10, [human]
        9830131G07,BB233602,Serpinb10,Serpinb10-ps, [mouse]
        BB233602,9830131G07,Serpinb10-ps, [mus-musculus]

        SerpinB10 相关文献

      • Riewald M. et al., 1995, J. Biol. Chem. 270: 26754-7.
      • Forsyth, S. et al., 2003, Genomics 81: 336-45. 
      • Horvath, AJ. et al., 2004, J. Mol. Evol. 59: 488-97.
      • Steenbakkers PJ. et al., 2008, Mycol. Res. 112 (Pt 8): 999-1006.
      • Przygodzka, P. et al., 2010, BMC Cell Biol. 11: 30. 
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