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小鼠 Thrombopoietin/THPO  抗体

All THPO Reagents

反应性: Mouse  
应用 : ELISA  WB  
50 µg 
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反应性: Mouse  
应用 : ELISA  
50 µg 
100 µg 
Add to Cart
    反应性: Mouse  
    应用 : ELISA  
    400 µg 
    200 µg 
    100 µg 
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      Thrombopoietin/THPO 相关研究领域

      Thrombopoietin/THPO 相关信号通路

        Thrombopoietin/THPO 相关蛋白、抗体、cDNA基因、ELISA试剂盒

        Thrombopoietin/THPO 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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        Thrombopoietin/THPO 概述&蛋白信息

        Thrombopoietin/THPO 相关资讯

        Thrombopoietin/THPO 研究背景

        基因概述: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene
        General information above from NCBI
        结构域: Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
        亚细胞定位: Secreted.
        相关疾病 : DISEASE: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
        相似的序列: Belongs to the EPO/TPO family. {ECO:0000305}.
        General information above from UniProt

        Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.

        Thrombopoietin/THPO 别称

        Thrombopoietin/THPO 相关文献

      • Ryu T,et al.(2003) Thrombopoietin-producing hepatocellular carcinoma. Intern Med. 42(8): 730-4.
      • Higashihara M,et al. (2003) Thrombopoietin-producing tumor. Intern Med. 42(8): 632-3?
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