Oligodendrocyte myelin glycoprotein (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All Oligodendrocyte myelin glycoprotein reagents are produced in house and quality controlled, including 3 Oligodendrocyte myelin glycoprotein Antibody, 39 Oligodendrocyte myelin glycoprotein Gene, 3 Oligodendrocyte myelin glycoprotein Lysate, 3 Oligodendrocyte myelin glycoprotein Protein, 2 Oligodendrocyte myelin glycoprotein qPCR. All Oligodendrocyte myelin glycoprotein reagents are ready to use.

Oligodendrocyte myelin glycoprotein 相关研究领域

Oligodendrocyte myelin glycoprotein 分子背景

Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein which contains eightLRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.

Oligodendrocyte myelin glycoprotein 参考文献

  • Viskochil D., et al.,(1991), The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol. Cell. Biol. 11:906-912.
  • Mikol D.D., et al., (1990), The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.J. Cell Biol. 110:471-479.
  • Mikol D.D., et al.,(1990), Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.J. Cell Biol. 111:2673-2679.