C1 inhibitor Matched ELISA Antibody Pair Set,Human

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C1 inhibitor Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
C1 inhibitor Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human C1 inhibitor
线性范围
62.5-4000 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of mouse anti-Human SerpinG1 / C1 inhibitor / C1IN monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10995-MM06)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human SerpinG1 / C1 inhibitor / C1IN monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 1 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10995-R018)
3. Standard Each vial contains 175 ng of recombinant Human SerpinG1 / C1 inhibitor / C1IN. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 4000 pg/mL is recommended.
产品概述
This C1 inhibitor Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human C1 inhibitor . It contains Human C1 inhibitor capture antibody, Human C1 inhibitor detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human C1 inhibitor protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

C1 inhibitor Matched ELISA Antibody Pair Set,Human 图片

C1 inhibitor Matched ELISA Antibody Pair Set,Human: 别称

C1IN Matched ELISA Antibody Pair Set, Human; C1INH Matched ELISA Antibody Pair Set, Human; C1NH Matched ELISA Antibody Pair Set, Human; HAE1 Matched ELISA Antibody Pair Set, Human; HAE2 Matched ELISA Antibody Pair Set, Human

C1 inhibitor 背景信息

Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.
全称
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
参考文献
  • Davis AE 3rd. et al. (2004) Biological effects of C1 inhibitor. Drug News Perspect. 17(7): 439-46.
  • Cicardi M, et al. (2005) C1 inhibitor: molecular and clinical aspects. Springer Semin Immunopathol. 27(3): 286-98.
  • Wouters D, et al. (2008) C1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor. Expert Opin Biol Ther. 8(8): 1225-40.
  • Cugno M, et al. (2009) C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress. Trends Mol Med. 15(2): 69-78.
  • Targeted Donor Complement Blockade After Brain-Death Prevents Delayed Graft Function In A Non-Human Primate Model Of Kidney Transplantation
    Author
    Danobeitia, JS;Zens, TJ;Chlebeck, PJ;Zitur, LJ;Reyes, JA;Eerhart, MJ;Coonen, J;Capuano, S;D'Alessandro, AM;Torrealba, JR;Burguete, D;Brunner, K;Van, E;Amersfoort, ;Ponstein-Simarro Doorten, Y;Van Kooten, C;Jankowska-Gan, E;Burlingham, W;Sullivan, J;Djamali, A;Pozniak, M;Yankol, Y;Fernandez, LA;
    Year
    2020
    Journal
    Am. J. Transplant.
    Application
    Complement assessment
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