COMP Matched ELISA Antibody Pair Set,Human

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COMP Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
COMP Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human COMP
线性范围
39.06-2500 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of mouse anti-Human COMP monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10173-MM02)
2. Detection Antibody 0.2 mg/mL of mouse anti-Human COMP monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.4 μg/mL in Dilution Buffer before use. (Catalog: # 10173-MM02)
3. Standard Each vial contains 80 ng of recombinant Human COMP. Reconstitute with 1 mL Dilution Buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in Dilution Buffer, and a high standard of 2500 pg/mL is recommended.
产品概述
This COMP Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human COMP . It contains Human COMP capture antibody, Human COMP detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human COMP protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

COMP Matched ELISA Antibody Pair Set,Human 图片

COMP Matched ELISA Antibody Pair Set,Human: 别称

EDM1 Matched ELISA Antibody Pair Set, Human; EPD1 Matched ELISA Antibody Pair Set, Human; MED Matched ELISA Antibody Pair Set, Human; PSACH Matched ELISA Antibody Pair Set, Human; THBS5 Matched ELISA Antibody Pair Set, Human

COMP 背景信息

Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
全称
cartilage oligomeric matrix protein
参考文献
  • Posey KL, et al. (2004) Role of TSP-5/COMP in pseudoachondroplasia. Int J Biochem Cell Biol. 36(6): 1005-12.
  • Chen FH, et al. (2005) Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 282(34): 24591-8.
  • Posey KL, et al. (2008) The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Curr Drug Targets. 9(10): 869-77.
  • Tan K, et al. (2009) The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 23(8): 2490-501.
  • CORRELATION STUDY OF SERUM CALCIUM LEVELS AND SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVELS IN RHEUMATOID ARTHRITIS PATIENTS IN BANDUNG, INDONESIA
    Author
    SAPTARINI, NM;WIBOWO, MS;GUSDINAR, T;
    Year
    2017
    Journal
    ASIAN JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH
    Application
    ELISA (serum)
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