CSF3R/G-CSFR Matched ELISA Antibody Pair Set,Human

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CSF3R/G-CSFR Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
CSF3R/G-CSFR Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human CSF3R/G-CSFR
线性范围
50-3200 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 0.5 mg/mL of mouse anti-Human G-CSF R / CD114 / CSF3R monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10218-MM06)
2. Detection Antibody 0.2 mg/mL of mouse anti-Human G-CSF R / CD114 / CSF3R monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10218-MM01)
3. Standard Each vial contains 215 ng of recombinant Human G-CSF R / CD114 / CSF3R. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3200 pg/mL is recommended.
产品概述
This CSF3R/G-CSFR Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human CSF3R/G-CSFR . It contains Human CSF3R/G-CSFR capture antibody, Human CSF3R/G-CSFR detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CSF3R/G-CSFR protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

CSF3R/G-CSFR Matched ELISA Antibody Pair Set,Human 图片

CSF3R/G-CSFR Matched ELISA Antibody Pair Set,Human: 别称

CD114 Matched ELISA Antibody Pair Set, Human; CSF3R Matched ELISA Antibody Pair Set, Human; G-CSF R Matched ELISA Antibody Pair Set, Human; GCSFR Matched ELISA Antibody Pair Set, Human

CSF3R/G-CSFR 背景信息

Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
全称
colony stimulating factor 3 receptor (granulocyte)
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参考文献
  • Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7.
  • Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6.
  • Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23.
  • Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.
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