CTLA-4 Matched ELISA Antibody Pair Set,Human

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CTLA-4 Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
CTLA-4 Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human CTLA-4
线性范围
15.63-1000 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of mouse anti-Human CTLA-4 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 1 μg/mL in PBS before coating. (Catalog: # 11159-MM06)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human CTLA-4 polyclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.35 μg/mL in Dilution Buffer before use.
3. Standard Each vial contains 200 ng of recombinant Human CTLA-4. Reconstitute with 1 mL Dilution Buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in Dilution Buffer, and a high standard of 1000 pg/mL is recommended.
产品概述
This CTLA-4 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human CTLA-4 . It contains Human CTLA-4 capture antibody, Human CTLA-4 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CTLA-4 protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

CTLA-4 Matched ELISA Antibody Pair Set,Human 图片

CTLA-4 Matched ELISA Antibody Pair Set,Human: 别称

ALPS5 Matched ELISA Antibody Pair Set, Human; CD Matched ELISA Antibody Pair Set, Human; CD152 Matched ELISA Antibody Pair Set, Human; CELIAC3 Matched ELISA Antibody Pair Set, Human; CTLA-4 Matched ELISA Antibody Pair Set, Human; GRD4 Matched ELISA Antibody Pair Set, Human; GSE Matched ELISA Antibody Pair Set, Human; IDDM12 Matched ELISA Antibody Pair Set, Human

CTLA-4 背景信息

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
全称
cytotoxic T-lymphocyte-associated protein 4
参考文献
  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.
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