gp130/IL6ST Matched ELISA Antibody Pair Set,Mouse

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gp130/IL6ST Matched ELISA Antibody Pair Set,Mouse 产品信息

产品名称
gp130/IL6ST Matched ELISA Antibody Pair Set,Mouse
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Mouse gp130/IL6ST
线性范围
11.72-750 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1.0 mg/mL of rabbit anti-mouse IL6ST monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 50135-R001)
2. Detection Antibody 0.2 mg/mL rabbit anti-mouse IL6ST monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody diluteion buffer before use. (Catalog: # 50135-R230).
3. Standard Each vial contains 60 ng of recombinant mouse IL6ST. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 750 pg/mL is recommended.
产品概述
This gp130/IL6ST Matched ELISA Antibody Pair Set,Mouse is a solid phase sandwich ELISA for quantitative determination of Mouse gp130/IL6ST . It contains Mouse gp130/IL6ST capture antibody, Mouse gp130/IL6ST detector antibody (HRP) and a highly purified HEK293-expressed recombinant Mouse gp130/IL6ST protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

gp130/IL6ST Matched ELISA Antibody Pair Set,Mouse 图片

gp130/IL6ST Matched ELISA Antibody Pair Set,Mouse: 别称

5133400A03Rik Matched ELISA Antibody Pair Set, Mouse; AA389424 Matched ELISA Antibody Pair Set, Mouse; BB405851 Matched ELISA Antibody Pair Set, Mouse; CD130 Matched ELISA Antibody Pair Set, Mouse; D13Ertd699e Matched ELISA Antibody Pair Set, Mouse; gp130 Matched ELISA Antibody Pair Set, Mouse

gp130/IL6ST 背景信息

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
全称
interleukin 6 signal transducer
Related Pathways
  • AKT Signaling Pathway
    AKT Signaling Pathway
  • Jak-Stat Signaling Pathway
    Jak-Stat Signaling Pathway
  • Autophagy Pathway
    Autophagy Pathway
  • IL12 signaling pathway
    IL12 signaling pathway
参考文献
  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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