GRO Beta/CXCL2 Matched ELISA Antibody Pair Set,Mouse

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GRO Beta/CXCL2 Matched ELISA Antibody Pair Set,Mouse 产品信息

产品名称
GRO Beta/CXCL2 Matched ELISA Antibody Pair Set,Mouse
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Mouse GRO Beta/CXCL2
线性范围
3.91-250 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of rabbit anti-Mouse GRO beta/CXCL2 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 50070-R019)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Mouse GRO beta/CXCL2 polyclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use.
3. Standard Each vial contains 7.3 ng of recombinant Mouse GRO beta/CXCL2. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 250 pg/mL is recommended.
产品概述
This GRO Beta/CXCL2 Matched ELISA Antibody Pair Set,Mouse is a solid phase sandwich ELISA for quantitative determination of Mouse GRO Beta/CXCL2 . It contains Mouse GRO Beta/CXCL2 capture antibody, Mouse GRO Beta/CXCL2 detector antibody (HRP) and a highly purified recombinant Mouse GRO Beta/CXCL2 protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

GRO Beta/CXCL2 Matched ELISA Antibody Pair Set,Mouse 图片

GRO Beta/CXCL2 Matched ELISA Antibody Pair Set,Mouse: 别称

CINC-2a Matched ELISA Antibody Pair Set, Mouse; Gro2 Matched ELISA Antibody Pair Set, Mouse; GROb Matched ELISA Antibody Pair Set, Mouse; Mgsa-b Matched ELISA Antibody Pair Set, Mouse; MIP-2 Matched ELISA Antibody Pair Set, Mouse; MIP-2a Matched ELISA Antibody Pair Set, Mouse; Mip2 Matched ELISA Antibody Pair Set, Mouse; Scyb Matched ELISA Antibody Pair Set, Mouse; Scyb2 Matched ELISA Antibody Pair Set, Mouse

GRO Beta/CXCL2 背景信息

Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.
全称
chemokine (C-X-C motif) ligand 2
研究领域
Related Pathways
  • IL17 signaling pathway
    IL17 signaling pathway
参考文献
  • Driscoll KE. (2000) TNFalpha and MIP-2: role in particle-induced inflammation and regulation by oxidative stress. Toxicol Lett. 112-113: 177-83.
  • Walpen S, et al. (2001) Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB J. 15(3): 571-3.
  • Fahey TJ, et al. (1990) Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine. 2(2): 92-9.
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