IL-37 Matched ELISA Antibody Pair Set,Human

For the orders from outside of China: MOQ 15 plates, lead time: 2 weeks.
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IL-37 Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
IL-37 Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human IL-37
线性范围
46.875-3000 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of mouse anti-Human IL-37/IL1F7 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10155-MM20)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human IL-37/IL1F7 polyclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.25 μg/mL in detection antibody dilution buffer before use.
3. Standard Each vial contains 82 ng of recombinant Human IL-37/IL1F7. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3000 pg/mL is recommended.
产品概述
This IL-37 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human IL-37 . It contains Human IL-37 capture antibody, Human IL-37 detector antibody (HRP) and a highly purified recombinant Human IL-37 protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

IL-37 Matched ELISA Antibody Pair Set,Human 图片

IL-37 Matched ELISA Antibody Pair Set,Human: 别称

FIL1 Matched ELISA Antibody Pair Set, Human; FIL1(ZETA) Matched ELISA Antibody Pair Set, Human; FIL1Z Matched ELISA Antibody Pair Set, Human; IL-1F7 Matched ELISA Antibody Pair Set, Human; IL-1H Matched ELISA Antibody Pair Set, Human; IL-1H4 Matched ELISA Antibody Pair Set, Human; IL-1RP1 Matched ELISA Antibody Pair Set, Human; IL-37 Matched ELISA Antibody Pair Set, Human; IL1F7 Matched ELISA Antibody Pair Set, Human; IL1H4 Matched ELISA Antibody Pair Set, Human; IL1RP1 Matched ELISA Antibody Pair Set, Human; IL37 Matched ELISA Antibody Pair Set, Human

IL-37 背景信息

Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy.
全称
interleukin 37
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Gao W, et al. (2003) Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol. 170 (1): 107-13.
  • Bufler P, et al. (2002) A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci. 99 (21): 13723-8.
  • Kumar S, et al. (2002) Interleukin-1F7B (IL-1H4 / IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine. 18 (2): 61-71.
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