IL-18Rβ / IL-18RAcP Matched ELISA Antibody Pair Set,Human

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IL-18Rβ / IL-18RAcP Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
IL-18Rβ / IL-18RAcP Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human IL-18Rβ / IL-18RAcP
线性范围
7.81-500 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of rabbit anti-Human IL18RAP / IL1R7 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10176-R033)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human IL18RAP / IL1R7 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10176-R122)
3. Standard Each vial contains 36 ng of recombinant Human IL18RAP / IL1R7. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 500 pg/mL is recommended.
产品概述
This IL-18Rβ / IL-18RAcP Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human IL-18Rβ / IL-18RAcP . It contains Human IL-18Rβ / IL-18RAcP capture antibody, Human IL-18Rβ / IL-18RAcP detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human IL-18Rβ / IL-18RAcP protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

IL-18Rβ / IL-18RAcP Matched ELISA Antibody Pair Set,Human 图片

IL-18Rβ / IL-18RAcP Matched ELISA Antibody Pair Set,Human: 别称

ACPL Matched ELISA Antibody Pair Set, Human; CD218b Matched ELISA Antibody Pair Set, Human; CDw218b Matched ELISA Antibody Pair Set, Human; IL-18R-beta Matched ELISA Antibody Pair Set, Human; IL-18RAcP Matched ELISA Antibody Pair Set, Human; IL-18Rbeta Matched ELISA Antibody Pair Set, Human; IL-1R-7 Matched ELISA Antibody Pair Set, Human; IL-1R7 Matched ELISA Antibody Pair Set, Human; IL-1RAcPL Matched ELISA Antibody Pair Set, Human; IL18RB Matched ELISA Antibody Pair Set, Human

IL-18Rβ / IL-18RAcP 背景信息

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand-binding subunit of the IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high-affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the etiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity, and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.
全称
interleukin 18 receptor accessory protein
研究领域
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.
  • Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.
  • Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.
  • Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms
    Author
    Wedervang-Resell, K;Friis, S;Lonning, V;Smelror, RE;Johannessen, C;Reponen, EJ;Lyngstad, SH;Lekva, T;Aukrust, P;Ueland, T;Andreassen, OA;Agartz, I;Myhre, AM;
    Year
    2019
    Journal
    Psychoneuroendocrinology
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