LAMP3/CD208 Matched ELISA Antibody Pair Set,Human

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LAMP3/CD208 Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
LAMP3/CD208 Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human LAMP3/CD208
线性范围
31.25-2000 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of rabbit anti-LAMP3 monoclonal antibody, Dilute to a working concentration of 2.0 μg/mL in CBS before coating. (Catalog: # 10527-R020)
2. Detection Antibody 0.5 mg/mL rabbit anti-LAMP3 monoclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to working concentration of 0.1 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10527-R002)
3. Standard Each vial contains 50 ng of recombinant LAMP3. Reconstitute standard powder with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve usi ng 2-fold serial dilutions in sample dilution buffer, and a high standard of 2000 pg/mL is recommended.
产品概述
This LAMP3/CD208 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human LAMP3/CD208 . It contains Human LAMP3/CD208 capture antibody, Human LAMP3/CD208 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human LAMP3/CD208 protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

LAMP3/CD208 Matched ELISA Antibody Pair Set,Human 图片

LAMP3/CD208 Matched ELISA Antibody Pair Set,Human: 别称

CD208 Matched ELISA Antibody Pair Set, Human; DC LAMP Matched ELISA Antibody Pair Set, Human; DC-LAMP Matched ELISA Antibody Pair Set, Human; DCLAMP Matched ELISA Antibody Pair Set, Human; LAMP Matched ELISA Antibody Pair Set, Human; LAMP-3 Matched ELISA Antibody Pair Set, Human; TSC403 Matched ELISA Antibody Pair Set, Human

LAMP3/CD208 背景信息

Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in the activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.
全称
lysosomal associated membrane protein 3
参考文献
  • Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
  • Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
  • Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.
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