SELL/CD62L Matched ELISA Antibody Pair Set,Human

For the orders from outside of China: MOQ 15 plates, lead time: 2 weeks.
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SELL/CD62L Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
SELL/CD62L Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human SELL/CD62L
线性范围
9.375-600 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 0.5 mg/mL of rabbit anti-Human CD62L / L-Selectin / SELL monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 11838-R037)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human CD62L / L-Selectin / SELL monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 11838-R018)
3. Standard Each vial contains 21 ng of recombinant Human CD62L / L-Selectin / SELL. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 600 pg/mL is recommended.
产品概述
This SELL/CD62L Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human SELL/CD62L . It contains Human SELL/CD62L capture antibody, Human SELL/CD62L detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human SELL/CD62L protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

SELL/CD62L Matched ELISA Antibody Pair Set,Human 图片

SELL/CD62L Matched ELISA Antibody Pair Set,Human: 别称

CD62L Matched ELISA Antibody Pair Set, Human; LAM1 Matched ELISA Antibody Pair Set, Human; LECAM1 Matched ELISA Antibody Pair Set, Human; LEU8 Matched ELISA Antibody Pair Set, Human; LNHR Matched ELISA Antibody Pair Set, Human; LSEL Matched ELISA Antibody Pair Set, Human; LYAM1 Matched ELISA Antibody Pair Set, Human; PLNHR Matched ELISA Antibody Pair Set, Human; TQ1 Matched ELISA Antibody Pair Set, Human

SELL/CD62L 背景信息

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
全称
selectin L
参考文献
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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