TLT-1/TREML1 Matched ELISA Antibody Pair Set,Human

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TLT-1/TREML1 Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
TLT-1/TREML1 Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human TLT-1/TREML1
线性范围
28.13-1800 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1 mg/mL of mouse anti-Human TLT-1 / TREML1 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 11934-MM15)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human TLT-1 / TREML1 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in Dilution Buffer before use. (Catalog: # 11934-R037)
3. Standard Each vial contains 45 ng of recombinant Human TLT-1 / TREML1. Reconstitute with 1 mL Dilution Buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in Dilution Buffer, and a high standard of 1800 pg/mL is recommended.
产品概述
This TLT-1/TREML1 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human TLT-1/TREML1 . It contains Human TLT-1/TREML1 capture antibody, Human TLT-1/TREML1 detector antibody (HRP) and a highly purified recombinant Human TLT-1/TREML1 protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

TLT-1/TREML1 Matched ELISA Antibody Pair Set,Human 图片

TLT-1/TREML1 Matched ELISA Antibody Pair Set,Human: 别称

dJ238O23.3 Matched ELISA Antibody Pair Set, Human; GLTL1825 Matched ELISA Antibody Pair Set, Human; MGC119173 Matched ELISA Antibody Pair Set, Human; PRO3438 Matched ELISA Antibody Pair Set, Human; TLT-1 Matched ELISA Antibody Pair Set, Human; TLT1 Matched ELISA Antibody Pair Set, Human; UNQ1825/PRO3438 Matched ELISA Antibody Pair Set, Human

TLT-1/TREML1 背景信息

Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
全称
triggering receptor expressed on myeloid cells like 1
参考文献
  • Washington A.V., et al., 2002, Blood 100:3822-4.
  • Allcock R.J.N., et al., 2003, Eur. J. Immunol. 33:567-77.
  • Washington A.V., et al., 2004, Blood 104:1042-7.
  • Barrow A.D., et al., 2004, J. Immunol. 172:5838-42.
  • Gattis J.L., et al., 2006,J. Biol. Chem. 281:13396-403.
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