TNFR2/TNFRSF1B Matched ELISA Antibody Pair Set,Mouse
For the orders from outside of China: MOQ 15 plates, lead time: 2 weeks.
TNFR2/TNFRSF1B Matched ELISA Antibody Pair Set,Mouse 产品信息
产品名称
TNFR2/TNFRSF1B Matched ELISA Antibody Pair Set,Mouse
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Mouse TNFR2/TNFRSF1B
线性范围
9.38-600 pg/mL
ELISA 抗体对套装（非即用型）组分
1. Capture Antibody 1.0 mg/mL of rabbit anti-mouse TNFRSF1B monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in CBS before coating. (Catalog: # 50128-R204)
2. Detection Antibody 0.5 mg/mL rabbit anti-mouse TNFRSF1B monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 50128-R340)
3. Standard Each vial contains 7 ng of recombinant mouse TNFRSF1B. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 0.6 ng/mL is recommended.
2. Detection Antibody 0.5 mg/mL rabbit anti-mouse TNFRSF1B monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 50128-R340)
3. Standard Each vial contains 7 ng of recombinant mouse TNFRSF1B. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 0.6 ng/mL is recommended.
产品概述
This TNFR2/TNFRSF1B Matched ELISA Antibody Pair Set,Mouse is a solid phase sandwich ELISA for quantitative determination of Mouse TNFR2/TNFRSF1B . It contains Mouse TNFR2/TNFRSF1B capture antibody, Mouse TNFR2/TNFRSF1B detector antibody
(HRP)
and a highly purified
HEK293-expressed
recombinant Mouse TNFR2/TNFRSF1B protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
TNFR2/TNFRSF1B Matched ELISA Antibody Pair Set,Mouse 图片
TNFR2/TNFRSF1B Matched ELISA Antibody Pair Set,Mouse: 别称
CD120b Matched ELISA Antibody Pair Set, Mouse; p75 Matched ELISA Antibody Pair Set, Mouse; TNF-alphaR2 Matched ELISA Antibody Pair Set, Mouse; TNF-R-II Matched ELISA Antibody Pair Set, Mouse; TNF-R2 Matched ELISA Antibody Pair Set, Mouse; TNF-R75 Matched ELISA Antibody Pair Set, Mouse; TNFalpha-R2 Matched ELISA Antibody Pair Set, Mouse; TNFBR Matched ELISA Antibody Pair Set, Mouse; Tnfr-1 Matched ELISA Antibody Pair Set, Mouse; Tnfr2 Matched ELISA Antibody Pair Set, Mouse; TNFR80 Matched ELISA Antibody Pair Set, Mouse; TNFRII Matched ELISA Antibody Pair Set, Mouse
TNFR2/TNFRSF1B 背景信息
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
全称
tumor necrosis factor receptor superfamily, member 1b
研究领域
参考文献
- Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
- Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
- Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
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