Anti-PD-1 Antibody

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-1 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

• Cancer Immunotherapy
• Co-inhibitory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Blockade: Blocking Antibodi
• Immune Checkpoint Blockade: PD1 / PDCD1 / CD2
• Immune Checkpoint Detection: Antibodies
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Detection: IHC Antibodies
• Immune Checkpoint Detection: WB Antibodies
• Immune Checkpoint Proteins
• Immune Checkpoint Targets
• Immunotherapy
• PD1 / PDCD1 / CD279 Immune Checkpoint
• PD1 / PDCD1 / CD279 Immune Checkpoint Antibod
• PD1 / PDCD1 / CD279 Immune Checkpoint Protein
• Targeted Therapy

programmed cell death 1

• Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>B7/CD28 Family
• Immunology>>Cluster of Differentiation (CD)>>T Cell CD Antigen>>CD Antigen (Regulatory T Cells)
• Immune Checkpoint>>Co-inhibitory Immune Checkpoint
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Co-stimulatory Molecules
• Cancer>>Signal Transduction>>ITIM/ITAM Immunoreceptors and Related Molecules
• Immunology>>Adaptive Immunity>>Regulatory T Cells
• Immunology>>Cluster of Differentiation (CD)>>T Cell CD Antigen

• James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
• Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
• del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
• Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.