题目 年份 作者 期刊 分子 货号 类别 应用
 Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism 2012 A Craney, C Ozimok, SM Pimentel-Elardo, A Capretta… Chemistry & biology FabI   protein enzyme
Fc containing polypeptides having increased anti-inflammatory properties and increased fcrn binding 2012 D Zha US Patent App. 14/357,779 FcRn   protein binding
Fcγ receptors        
Fusion proteins for the treatment of allergic diseases 2012 MMBW Dooper, B Bogen, HR Myrset US 20140120123 A1 FcγRIIb   protein   
FcγRIIb   antibody   
Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus 2012 Fu TM, Wang D, Freed DC, Tang A, Li F, He X, Cole S, Dubey S, Finnefrock AC, ter Meulen J, Shiver JW, Casimiro DR. Vaccine gB   protein as Vaccines
Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures 2012 Zhang, Y;Shi, Y;Qiao, L;Sun, Y;Ding, W;Zhang, H;Li, N;Chen, D; Brain Res. gp120   protein   
Thermal-sensitive hydrogel as adjuvant-free vaccine delivery system for H5N1 intranasal immunization 2012 Wu, Y;Wei, W;Zhou, M;Wang, Y;Wu, J;Ma, G;Su, Z; Biomaterials HA   protein   
A mild and reliable method to label enveloped virus with quantum dots by copper-free click chemistry 2012 Hao, J;Huang, LL;Zhang, R;Wang, HZ;Xie, HY; Anal. Chem. HA   antibody   
Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism 2012 Fang, Y;Banner, D;Kelvin, AA;Huang, SS;Paige, CJ;Corfe, SA;Kane, KP;Bleackley, RC;Rowe, T;Leon, AJ;Kelvin, DJ; J. Virol. HA   protein ELISA for the quantification of  anti-HA antibody (coating antigen)
Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities 2012 Hamilton, BS;Gludish, DW;Whittaker, GR; J. Virol. HA   gene   
Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus 2012 Josset, L;Engelmann, F;Haberthur, K;Kelly, S;Park, B;Kawoaka, Y;García-Sastre, A;Katze, MG;Messaoudi, I; J. Virol. HA   protein ELISA for the quantification of  anti-HA antibody (coating antigen)
Introduction of silent mutations into the NP gene of influenza A viruses as a possible strategy for the creation of a live attenuated vaccine 2012 Anhlan, D;Hrincius, ER;Scholtissek, C;Ludwig, S; Vaccine HA   antibody WB to detect HA expression in cell lysates
Setting up a platform for plant-based influenza virus vaccine production in South Africa 2012 Mortimer, E;Maclean, JM;Mbewana, S;Buys, A;Williamson, AL;Hitzeroth, II;Rybicki, EP; BMC Biotechnol. HA   protein WB indicating the presence of H5-specific antibodies in sera from mice
Molecular adjuvant Ag85A enhances protection against influenza A virus in mice following DNA vaccination 2012 Dai, J;Pei, D;Wang, B;Kuang, Y;Ren, L;Cao, K;Wang, H;Zuo, B;Shao, J;Li, S;Li, H;Li, M; Viruses HA 11048-V08H4 protein Serological Assays by ELISA to detect serum antibody (coating antigen)
An inhalational antiviral strategy for the potential use of nitric oxide during influenza infection 2012 McMullin, BB; Thesis HA   protein Nitrosylation Assay
Fabrication and Characterization of Glass Spheres & SU-8 Mixture Mold and Its Microchannel for an Electrochemical Immunosensor 2012 Y Nam, YK Pak, JJ Pak Conference abstract HA   ELISA kit   
Immobilized sialyloligo-macroligand and its protein binding specificity 2012 Narla, SN;Sun, XL; Biomacromolecules HA   protein binding
A VLP vaccine induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza A virus 2012 Wu, CY;Yeh, YC;Chan, JT;Yang, YC;Yang, JR;Liu, MT;Wu, HS;Hsiao, PW; PLoS ONE HA 11684-V08H protein WB analysis of VLP-induced humoral immunity against HA (detection antigen)immune sera
HA 11055-RM05 antibody a modified plaque reduction assay to determine the virus-neutralizing activities of 
Binding Molecule Having Influenza A Virus-Neutralizing Activity Produced from Human B Cell 2012 SJ Chang, KS Kwon, KS Yi, HJ Lee… US 20140234336 A1 HA1 11056-V08H1 protein   
The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus 2012 Cao, Z;Meng, J;Li, X;Wu, R;Huang, Y;He, Y; PLoS ONE HA2   antibody splenocytes stimulation
IgG    service   
Methods for measuring hdl subpopulations 2012 SW Altmann US 20140243233 A1 HRG   antibody   
Aptamer that binds to the gD protein of herpes simplex virus 1 and efficiently inhibits viral entry 2012 Gopinath, SC;Hayashi, K;Kumar, PK; J. Virol. HVEM   protein binding
PVRL1   protein   
Quantitative modeling assesses the contribution of bond strengthening, rebinding and force sharing to the avidity of biomolecule interactions 2012 VL Schiavo, P Robert, L Limozin, P Bongrand PloS one ICAM1   protein Surface and Bead Functionalization
Expression and characterization of full length Interferon gamma in mammalian cells 2012 Kiiskinen, NM; Thesis IFNGR1   protein standard
Method for Diagnosing or Determining the Prognosis of Colorectal Cancer (CRC) Using Novel Autoantigens: Gene Expression Guided Autoantigen Discovery 2012 MJ Lim, C Sears, KJ Rothschild US 20130040839 A1 IGF2BP2   protein   
Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells 2012 Wu, YC;Zhu, M;Robertson, DM; PLoS ONE IGFBP3 10430-H07H protein cell-based (proliferation)
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus 2012 Quadrato, G;Benevento, M;Alber, S;Jacob, C;Floriddia, EM;Nguyen, T;Elnaggar, MY;Pedroarena, CM;Molkentin, JD;Di Giovanni, S; Proc. Natl. Acad. Sci. U.S.A. IgG1-Fc   protein   
Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity 2012 Dai, Y;Chen, H;Mo, C;Cui, L;He, W; J. Biol. Chem. IgG1-Fc   protein binding
Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1β release and macrophage transepithelial migration 2012 Lamont, EA;O'Grady, SM;Davis, WC;Eckstein, T;Sreevatsan, S; Infect. Immun. IL1B   protein   
Single-walled carbon nanotubes induce fibrogenic effect by disturbing mitochondrial oxidative stress and activating NF-κB signaling 2012 Xiaoqing, H; Journal of Clinical Toxicology IL1B   gene PCR
Interleukin-33 induces interleukin-17F in bronchial epithelial cells 2012 Fujita, J;Kawaguchi, M;Kokubu, F;Ohara, G;Ota, K;Huang, SK;Morishima, Y;Ishii, Y;Satoh, H;Sakamoto, T;Hizawa, N; Allergy IL1RL1   protein standard
Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress 2012 Zhang, HF;Xie, SL;Chen, YX;Mai, JT;Wang, JF;Zhu, WL;Zhu, LG; J Transl Med IL33 10368-HNAE protein cell-based (culture)
ST2   protein   
Prolonged inhibition of interleukin-6 mediated signaling 2012 JB Holz, S Rossenu, S De Bruyn… US 20140212417 A1 IL6   ELISA kit   
Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes 2012 Basak, JM;Verghese, PB;Yoon, H;Kim, J;Holtzman, DM; J. Biol. Chem. LDLR 50305-M08H protein   
PCSK9 50251-M08H protein   
Prevalence of intracellular galectin-1-expressing lymphocytes in umbilical cord blood in comparison with adult peripheral blood 2012 Kollár, S;Sándor, N;Molvarec, A;Stenczer, B;Rigó, J;Tulassay, T;Vásárhelyi, B;Toldi, G; Biol. Blood Marrow Transplant. LGALS1 10290-HNAE protein cell-based (proliferation)
Engineered microbe-targeting molecules and uses thereof 2012 DE Ingber, M Super, JC Way, MJ Cartwright… US 20140227723 A1 MBL   protein   
Mic-binding antibodies and methods of use thereof 2012 JD Wu US 20120315287 A1 MICB 10759-H08H protein   
Regulation of substance P and Neurokinin-1 receptor expression in a mouse model of acute pancreatitis 2012 HUA - 2012, KOHY; Thesis MME   protein animal injection
Upconversion fluorescence resonance energy transfer based biosensor for ultrasensitive detection of matrix metalloproteinase-2 in blood 2012 Y Wang, P Shen, C Li, Y Wang, Z Liu Analytical chemistry MMP1   protein enzyme
Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-α converting enzyme (TACE/ADAM-17) 2012 Qiu, Z;Yan, M;Li, Q;Liu, D;Van den Steen, PE;Wang, M;Opdenakker, G;Hu, J; J Enzyme Inhib Med Chem MMP8   protein enzyme
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function 2012 Jin, J;Sison, K;Li, C;Tian, R;Wnuk, M;Sung, HK;Jeansson, M;Zhang, C;Tucholska, M;Jones, N;Kerjaschki, D;Shibuya, M;Fantus, IG;Nagy, A;Gerber, HP;Ferrara, N;Pawson, T;Quaggin, SE; Cell NA   protein enzyme
Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes 2012 Mestankova, H;Schirmer, K;Escher, BI;von Gunten, U;Canonica, S; Environ. Pollut. NA 11058-VNAHC protein Neuraminidase inhibition assay
Synthesis of novel N-acetylneuraminic acid derivatives as substrates for rapid detection of influenza virus neuraminidase 2012 Yang, W;Liu, X;Peng, X;Li, P;Wang, T;Tai, G;James Li, X;Zhou, Y; Carbohydr. Res. NA   protein neuraminidase and luciferase reactions
Mechanistic analysis of polymer-attached inhibitors of influenza virus and their effect on minimizing drug resistance 2012 Lee, CMJCM; Thesis NA   protein NA specificity binding assays
Identification of small molecules that interfere with H1N1 influenza A viral replication 2012 A Bottini, SK De, BJG Baaten, B Wu, E Barile… ChemMedChem NA 11058-V07B protein Fluorescent neuraminidase assays
Neutrophil gelatinase-associated lipocalin regulates intracellular accumulation of Rh123 in cancer cells 2012 Wang, LH;Chang, GQ;Zhang, HJ;Wang, J;Lin, YN;Jin, WN;Li, HW;Gao, W;Wang, RJ;Li, QH;Pang, TX; Genes Cells NGAL   protein cell-based (culture)
β-Nerve growth factor is a major component of alpaca seminal plasma and induces ovulation in female alpacas 2012 Kershaw-Young, CM;Druart, X;Vaughan, J;Maxwell, WM; Reprod. Fertil. Dev. NGF 11050-HNAC protein   
 Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E- … 2012 M Boehm, B Hoy, M Rohde, N Tegtmeyer, KT Bæk… Gut Pathogens NTF   protein Cleavage assays of purified HtrA
Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD 2012 Gersemann, M;Becker, S;Nuding, S;Antoni, L;Ott, G;Fritz, P;Oue, N;Yasui, W;Wehkamp, J;Stange, EF; J Crohns Colitis OLFM4 11639-H08H protein Binding
Synthetic small peptides acting on B7H1 enhance apoptosis in pancreatic cancer cells 2012 Wang, F;Ma, J;Liu, J;Jin, H;Huang, D; Mol Med Rep PD1   protein cell-based (apoptosis)
human IgG        
Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts 2012 JA Giménez-Bastida, M Larrosa… J. Agric. Food Chem. PDGFRB SEK10514 ELISA kit Measurement of Growth Factors, Adhesion Molecules, and Cytokines by ELISA
Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF‐α‐induced inflammation and associated molecular markers in human … 2012 JA Giménez‐Bastida… Mol. Nutr. Food Res.  PDGFRB SEK10514 ELISA kit Measurement of adhesion molecules, growth factors and cytokines by enzyme-linked immunosorbent assay (ELISA)
Composition of 5-nitrobenzoate derivatives as anti-metastatic agent that inhibits tumor cell-induced platelet aggregation 2012 CP Tseng, PW Hsieh, YW Chang US 20140011882 A1 PDPN   protein   
Polycistronic Expression of Human Platelet Factor 4 with Heparin-Neutralizing Activity in Escherichia coli 2012 Y Duan, Z Wang, W Wu, Z Fang… Bioscience, biotechnology and biochemstry. PF4   protein Enterokinase cleavage and mass spectrometric identification
Rational design of selective organoruthenium inhibitors of protein tyrosine phosphatase 1B 2012 JX Ong, CW Yap, WH Ang Inorganic chemistry PTP1B   protein PTP Inhibition Assays and Enzymatic Kinetic Studies.
Organometallic Scaffolds as Protein Tyrosine Phosphatase 1B Inhibitor 2012 ONGJUN XIANG Thesis PTP1B   protein PTP Inhibition Assays and Enzymatic Kinetic Studies.
The therapeutic function of the chemokine RANTES on the H22 hepatoma ascites model 2012 Hao, C;Shi, Y;Yu, J;Wei, X;Li, S;Tong, Z; Mol. Cell. Biochem. RANTES 10900-H14H protein   
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5 2012 Ruffner, H;Sprunger, J;Charlat, O;Leighton-Davies, J;Grosshans, B;Salathe, A;Zietzling, S;Beck, V;Therier, M;Isken, A;Xie, Y;Zhang, Y;Hao, H;Shi, X;Liu, D;Song, Q;Clay, I;Hintzen, G;Tchorz, J;Bouchez, LC;Michaud, G;Finan, P;Myer, VE;Bouwmeester, T;Porter, J;Hild, M;Bassilana, F;Parker, CN;Cong, F; PLoS ONE RSPO1   protein STF Assay
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake 2012 ÖH Yilmaz, P Katajisto, DW Lamming, Y Gültekin… Nature RSPO1   protein   
S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells 2012 Chen, D;Zheng, XF;Yang, ZY;Liu, DX;Zhang, GY;Jiao, XL;Zhao, H; World J. Gastroenterol. S100A4   gene plasmid construction

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