B7-H3 qPCR Primer Pairs, Rat

B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

• Cancer Immunotherapy
• Co-inhibitory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Detection: Antibodies
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Detection: FCM Antibodies
• Immune Checkpoint Detection: ICC Antibodies
• Immune Checkpoint Detection: IP Antibodies
• Immune Checkpoint Detection: WB Antibodies
• Immune Checkpoint Targets
• Immunotherapy
• Targeted Therapy

CD276 molecule

• Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>B7/CD28 Family
• Immune Checkpoint>>Co-inhibitory Immune Checkpoint
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Co-stimulatory Molecules
• Immunology>>Cluster of Differentiation (CD)>>Natural Killer (NK) Cell CD Antigen
• Immunology>>Cluster of Differentiation (CD)>>T Cell CD Antigen
• Stem Cells>>Hematopoietic Progenitors>>Lymphoid>>T Lymphocytic Lineage

• Suh WK, et al. (2004) The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A. 101(35): 12969-73.
• Waschbisch A, et al. (2008) Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Arthritis Rheum. 58(11): 3600-8.
• Loos M, et al. (2010) B7-h3 and its role in antitumor immunity. Clin Dev Immunol. 2010: 683875.
• Zang X, et al. (2010) Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 23(8): 1104-12.
• Sun J, et al. (2010) Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 59(8): 1163-71.