| CD11b Gene ID | 3684 |
| CD11b Official Full Name | integrin subunit alpha M |
| CD11b Alias | ITGAM, CR3A, MO1A, MAC-1, MAC1A, SLEB6 |
| CD11b Cellular Expression | T; B; NK; Dendritic; Macrophage; monocytes |
| CD11b Ligand/Receptor/Association | CD54, iC3b and ECM , CD242 |
| CD11b Function | cell adhesion, and immune response |
| CD11b Summary | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
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