| CD286 Gene ID | 10333 |
| CD286 Official Full Name | toll like receptor 6 |
| CD286 Alias | TLR6 |
| CD286 Cellular Expression | Dendritic; Epithelial; Granulocyte; Macrophage; monocytes |
| CD286 Ligand/Receptor/Association | lipoproteins, glycans |
| CD286 Function | Receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins |
| CD286 Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011] |
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