Cluster of differentiation 3ε/ CD3ε

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CD3ε / CD3E Antibody, Rabbit PAb, Antigen Affinity Purified by WB application

Caption: Immunochemical staining of human CD3D in human spleen with mouse Mab (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of T cells.

CD3ε / CD3e / CD3 epsilon Antibody, Rabbit MAb by IP application

Human CD3ε / CD3e Antibody by FC Application

Caption:
CD3+ T cell staining of lymphocytes using Human CD3 (humanized OKT3) antibody by Flow cytometric analysis. A: Lymphocytes were stained with both PE-conjugated CD3(humanized OKT3) antibody and OKT3-FITC-eBioscience (eBioscience, 11-0037-41). B: Lymphocytes were stained with PE-conjugated humanized OKT3 antibody and CD19-APC (BD, 555415).

 

Caption:
Flow cytometric analysis of Human CD3 expression on human peripheral blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD3 and APC conjugated anti-Human CD19 (BD Pharmingen™ Cat. No. 555415). The dot plots were derived from events with the forward and side light-scatter characteristics of viable lymphocytes.