| CD331 Gene ID | 2260 |
| CD331 Official Full Name | fibroblast growth factor receptor 1 |
| CD331 Alias | FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM |
| CD331 Cellular Expression | Endothelial; Epithelial |
| CD331 Ligand/Receptor/Association | aFGF, bFGF, K-FGF |
| CD331 Function | Receptor for basic fibroblast growth factor. |
| CD331 Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] |
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