| CD49f Gene ID | 3655 |
| CD49f Official Full Name | integrin subunit alpha 6 |
| CD49f Alias | VLA-6, ITGA6 |
| CD49f Cellular Expression | T; Endothelial; Epithelial; Macrophage; monocytes; Platelet; Stem cell |
| CD49f Ligand/Receptor/Association | laminins, invasin |
| CD49f Function | Embryogenesis, adhesion and cell migration |
| CD49f Summary | The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] |
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