| CD59 Gene ID | 966 |
| CD59 Official Full Name | CD59 molecule |
| CD59 Alias | Protectin, MAC- inhibitor |
| CD59 Cellular Expression | T; NK; Erythrocyte; Granulocyte; Macrophage |
| CD59 Ligand/Receptor/Association | C8a, C9 |
| CD59 Function | Prevents complement polymerization. Protects cells from complement mediated lysis |
| CD59 Summary | CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[1]CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[2] Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[3]Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[4 |
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