The Human Leukocyte Differentiation Antigen workshop Ⅴ (HLDA5), held in Boston, USA, in November 1993. Those present at this meeting represent the efforts of more than 500 laboratories worldwide who have jeoined together over a 2-year period to analyze 1,450 antibodies and characterize more than 150 molecules. Blind panels for all monoclonal antibodies (MoAbs) including every CD antigens, every known candidate for CD status, and all MoAbs of undefined specificity, were analyzed by flow cytometry. Other dedicated laboratories undertook serologic, molecular, biochemical,and histochemical characterization of the MoAbs and the structures they defined. The results obtained by all groups showed almost perfect concordance. Detailed results of these studies will be published separately. Based on these findings, the workshop organizers are pleased to recommend the adoption of 48 new CD clusters and subclusters and the redefinition of 14 previously established clusters. Table1 summarizes the additions and changes made to the existing CD nomenclature.
| New CD | Alias | Function |
|---|---|---|
| CD16b | FcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3 | Low affinity Fc receptor |
| CD32 | FCG2, FCGR2A1, FCGR2 | Regulation of B-cell function. Induces phagocytosis and mediator release. |
| CD42a | ||
| CD42b | ||
| CD42c | GPIbb,GPIBB | Platelet adhesion and aggregation |
| CD42d | ||
| CD44 | H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III | Cell adhesion and migration |
| CD44R | ||
| CD49a | ||
| CD49b | VLA-2, ITGA2 | Adhesion and platelet aggregation. |
| CD49c | VLA-3, ITGA3 | Adhesion and signal transduction |
| CD49d | ||
| CD49e | VLA-5, ITGA5 | Adhesion, regulation of cell survival and apoptosis |
| CD49f | VLA-6, ITGA6 | Embryogenesis, adhesion and cell migration |
| CD50 | ICAM-3 | Adhesion and costimulation |
| CD51 | Vitronectin receptor, ITGAV, MSK8 | Adhesion and signal transduction |
| CD52 | CAMPATH-1, HE5, CDW52 | Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity |
| CD62E | E-selectin, ELAM-1, SELE | Tumor cell adhesion and angiogenesis |
| CD62L | L-selectin, LECAM-1, SELL | Leukocyte rolling and homing on activated endothelium |
| CD62P | P-selectin, PADGEM, SELP, LECAM3 | Cell adhesion |
| CD66a | BGP-1, NCA-160, CEACAM1 | Neutrophil activation, homophilic and heterophilic adhesion |
| CD66b | CD67, CGM6, CEACAM8 | Cell adhesion and neutrophil activation |
| CD66c | NCA, CEACAM6 | Cell adhesion and neutrophil activation |
| CD66d | CGM1, CEACAM3 | Cell adhesion and neutrophil activation |
| CD66e | CEA, CEACAM5 | Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells |
| CD67 | ||
| CD70 | Ki-24, CD27L, TNFSF7 | Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation. |
| CDw76 | ||
| CD79a | MB1, IGA, Ig-alpha | Subunit of B-cell antigen receptor.Signal transduction |
| CD79b | B29, IGB, Ig-beta | Subunit of B-cell antigen receptor.Signal transduction |
| CD80 | B7, B7-1, BB1 | Costimulation of T-cell activation and proliferation. |
| CD81 | TAPA-1, Tetraspanin-28 | Signal transduction and Cell adhesion |
| CD82 | R2, KAI1, Tetraspanin-27 | Signal transduction |
| CD83 | HB15 | Antigen presentation and immune stimulation |
| CDw84 | ||
| CD85 | ||
| CD86 | B70, B7-2, CD28LG2 | Costimulation of T-cell activation and proliferation |
| CD87 | UPA-R, PLAUR, MO3 | Cell chemotaxis and adhesion |
| CD88 | ||
| CD89 | FcαR, FCAR | IgA Fc receptor |
| CDw90 | ||
| CD91 | LRP1,A2MR,APOER | Endocytic receptor involved in intracellular signaling, lipid homeostasis, and phagocytosis of apoptotic cells |
| CDw92 | ||
| CD93 | C1qR, C1QR1, MXRA4 | Cell adhesion and clearance of apoptotic cells |
| CD94 | ||
| CD95 | Apo-1, FASLG, APTL, TNFRSF6 | Induces apoptosis |
| CD96 | TACTILE | Involved in adhesive interactions of activated T cells and NK cells |
| CD97 | ADGRE5 | Neutrophil migration, cell adhesion and signaling |
| CD98 | 4F2hc, SLC3A2, MDU1 | Cell activation and cell aggregation |
| CD99 | MIC2, E2 | Leukocyte migration, T-cell activation and cell adhesion |
| CD99R | ||
| CD100 | Semaphorin 4D, SEMA4D | Enhancement of B-cell and dendritic cell responses |
| CDw101 | ||
| CD102 | ICAM-2 | Adhesion, costimulation and lymphocyte recirculation |
| CD103 | HUMINAE, ITGA1 | Lymphocyte retention. Receptor for E-cadherin. |
| CD104 | ||
| CD105 | Endoglin, ENG, END | Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1 |
| CD106 | VCAM-1, L1CAM | Leukocyte adhesion. Transmigration and costimulation of T-cells. |
| CD107a | LAMP-1 | Cell adhesion |
| CD107b | LAMP-2 | May be involved in leukocyte adhesion.Implicated in tumor cell metastasis |
| CDw108 | ||
| CDw109 |
