Structure of Complement Proteins

Complement Component / Protein Structure Information

Gene ID Description Classification Pdb code 3D Structure
C1R,C1RL complement C1r hydrolase 1MD7
C1S,C1S1,C1SA complement C1s hydrolase 4J1Y
complement C1q A-C signaling protein 5HKJ
C1QL1, C1QL2,
complement C1q like 1-4 protein binding 4QQ2
MASP1,MASP2 mannan binding lectin serine peptidase 1,2 structural protein 4IGD
CFD complement factor D hydrolase 5FBI
C1QBP complement C1q binding protein protein binding 3RPX
C4BPB complement C4 immune system 5JPM

Complement Component / Protein Structure References

1. Budayova-Spano M, et al. (2002). Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism. Structure, 10(11), 1509-1519.
2. Perry A J, et al. (2013). A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. Journal of Biological Chemistry, 288(22), 15821-15829.
3. Moreau C, et al. (2016). Structural and functional characterization of a single-chain form of the recognition domain of complement protein C1q. Frontiers in immunology, 7.
4. Ressl S, et al. (2015). Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily. Structure, 23(4), 688-699.
5. Megyeri M, et al. (2013). Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway. Journal of Biological Chemistry, 288(13), 8922-8934.
6. Croll T I, et al. (2016). Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallographica Section D: Structural Biology, 72(9).