Structure of Complement Regulators

Complement Receptor Structure Information

Gene ID Description Classification Pdb code 3D Structure
CFH complement factor H immune system 4ZH1
complement factor H related 1-5 immune system 5EA0
CD46 membrane cofactor protein, MCP viral protein/protein binding 3L89
CD55 serpin family G member 1 hydrolase inhibitor 5DU3
SERPING1 mannan binding lectin serine peptidase 1,2 structural protein 4IGD
C4BPA,C4BPB complement component 4 binding protein alpha immune system 5HYT

Complement Regulator Structure References

1. Blaum B S, et al. (2015). Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations. Glycobiology, cwv170.
2. Maibaum J, et al. (2016). Small-molecule factor D inhibitors targeting the alternative complement pathway. Nature Chemical Biology.
3. Cupelli K, et al. (2010). Structure of adenovirus type 21 knob in complex with CD46 reveals key differences in receptor contacts among species B adenoviruses. Journal of virology, 84(7), 3189-3200.
4. Yoder J D, et al. (2012). The crystal structure of a coxsackievirus B3-RD variant and a refined 9-angstrom cryo-electron microscopy reconstruction of the virus complexed with decay-accelerating factor (DAF) provide a new footprint of DAF on the virus surface. Journal of virology, 86(23), 12571-12581.
5. Buffalo C Z, et al. (2016). Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nature Microbiology, 1, 16155.