Among all cytokine receptors, none has such a profound and broad effect on the adaptive immune system as the gamma-chain cytokine receptor. IL-4, IL-7, IL-9 and IL-21 bind a heterodimeric receptor comprised of the γc and the specific receptor subunits, IL-4R, IL-7R (CD127), IL-9R and IL-21R chain, respectively. IL-2 and IL-15 bind a heterotrimeric receptor composed of the specific IL-2R (CD25) or IL-15R chain, and the shared IL-2/15R (CD122) and γc chains.
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Below are members of common gamma-chain (γc) receptor family, and its cognate ligands. They are classified into this family because they share the common gamma-chain receptor.
|CD122 / IL-2RB||IL2/IL-2/Interleukin-2, IL15/IL-15/Interleukin 15|
|CD132 / IL2RG||IL-2, IL-4, IL-7, IL-9, IL-15, IL-21|
|CD215/IL-15 R alpha||IL15/IL-15/Interleukin 15|
The common gamma-chain (γc) is critical for ligand binding and signaling by common gamma-chain (γc) cytokines. All γc family cytokines similarly activates the Janus kinase (JAK)-family protein tyrosine kinases JAK1 and JAK3, with JAK1 binding a unique α or β chain and JAK3 binding the common gamma-chain (γc). They exert its effect through interaction with gamma-chain (γc) cytokine receptor complex, which is composed of a unique receptor chain and the common gamma-chain (γc).
The following are outlines of "Common Gamma-Chain Receptor Family Review Page", which briefly introduce each member of common Gamma-chain cytokine family. If you want more details, please click here.
|• Common Gamma-Chain Receptor||• Other Receptors In Common Gamma-Chain Receptor Family|