Interleukin-1 (IL-1) receptors family is a large family of molecules of key importance in mediating the activation of innate immunity, the first line of defense against pathogenic microorganisms. Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb).
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All IL-1 receptor family members possess three immunoglobulin (Ig)-like domains in the extracellular receptor segment. Notable exceptions are SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP (IL-1 receptor family subtype), which have only one Ig-like domain.
Apart from IL-1R2, almost all IL-1 receptor family members have an intracellular TIR (Toll-like receptor/IL-1 R signaling) domain. IL-1R2, although lacking a TIR domain, is considered part of this subgroup due to its high similarity to the IL-1R1.
|IL-1 receptor complex||IL1R1/IL-1R1/IL-1 RI||IL1A/IL-1A/IL-1F1, IL1B/IL-1B/IL-1 beta, IL-1RA/IL1RN||2q12|
|IL-1 receptor complex||IL-1R2/CD121b||IL1A/IL-1A/IL-1F1, IL1B/IL-1B/IL-1 beta, IL-1RA/IL1RN||2q12|
|IL-1 receptor complex||IL-1RAcP/IL-1R3||Signaling component||3q28|
|IL-33 receptor complex||IL1RL1/IL-1 R4||IL-33||2q12|
|IL-18 receptor complex||IL18R1||IL18/IL-18/Interleukin 18, IL37 / IL1F7 / IL-1H4||2q12|
|IL-36 receptor complex||IL1RL2/IL1RRP2||IL-1F6/IL36A, IL36B/IL1F8, IL36G/IL-1F9, IL-1F5/IL36RN, IL1F10 / IL-38||2q12|
|IL-18 receptor complex||IL18RAP||Signaling component||2q12|
|IL-18 receptor complex||IL18BP / IL18BPa||IL18/IL-18/Interleukin 18, IL37 / IL1F7 / IL-1H4||11q13|
|Orphan receptors||IL-1R8/IL1RAPL1||Orphan receptor||Xp22|
|Orphan receptors||IL-1R9/IL1RAPL2||Orphan receptor||Xp22|
|Orphan receptors||SIGIRR/TIR8||Orphan receptor||11p15.5|
Six IL-1 receptor family members (IL-1 R1, IL-1 R2, IL-1 R4, IL-1 R5, IL-1 R6 and IL-1 R7) are located on chromosome 2. IL-1 R3 is located on chromosome 3, IL-1 R8 and IL-1 R9 are located on the X chromosome, and IL-18BP and SIGIRR lies on chromosome 11.
The following are outlines of "IL-1 Receptor Family Review Page", which briefly introduce each IL-1 family receptor. If you want more details, please click here.
1. IL-1 receptor complex: IL-1R1, IL-R2 and IL-R3
2. IL-33 receptor complex: IL-1R4
3. IL-18 receptor complex: IL-1R5, IL-R7 and IL-18BP
4. IL-36 receptor complex: IL-1R6
5. Orphan receptors: IL-1R8, IL-R9 and SIGIRR/TIR8