IL-10 Family Ligand

IL-10 family ligands can be classified into three subgroups based primarily on their biological functions. The first group contains only IL-10 itself. The second group, namely IL-20 subfamily ligands, is composed of IL-19, IL-20, IL-22, IL-24, and IL-26. The last group is the type III interferon/IFN group (or IFN λs), which contains the closely related cytokines IL-28A, IL-28B, and IL-29.

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IL-10 Family Ligand Table

IL-10 includes six alpha-helices. Classification of the IL-10 family is based on sequence analysis and three-dimensional structure of human interleukin 10 and Epstein-Barr viral interleukin 10. Though some IL-10 family members such as IL-19 shares limited overall aa homology to IL-10 (21%), it has conserved IL-10's alpha-helical structure.

The following table lists IL-10 family ligands, its categories, identity with human IL-10, aggregation state and its corresponding IL-10 receptors.

Category Ligand % identity with hIL-10 Aggregation state Receptor
IL-10 subfamily IL-10 100 Dimer CD219 / IL10RA, IL10RB / IL-10RB
IL-20 subfamily IL-19 21 Monomer IL20RA/IL-20RA, IL20RB
IL-20 subfamily IL-20 29 Monomer IL20RA/IL-20RA, IL20RB
IL-20 subfamily IL-22 26 Monomer IL-22R / IL22RA1, IL-22BP/IL-22RA2
IL-20 subfamily IL-24 24 Monomer IL20RA/IL-20RA, IL20RB
IL-20 subfamily IL-26 27 Dimer IL10RB / IL-10RB, IL20RA/IL-20RA
type III IFN group IFN-λ1 Low Monomer IL-28 R alpha/IFN-lambda R1
type III IFN group IFN-λ2 Low Monomer IL-28 R alpha/IFN-lambda R1, IL10RB / IL-10RB
type III IFN group IFN-λ3 Low Monomer IL-28 R alpha/IFN-lambda R1, IL10RB / IL-10RB

IL-10 Family Ligand Review

IL-10 family of cytokines includes nine members, namely IL-10, IL-19, IL-20, IL-22, IL-24 (MDA-7), IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. These cellular cytokines, as well as several cytokines encoded in viral genomes (viral cytokines), form a family of IL-10-related cytokines, the IL-10 family.

The interaction of these cytokines with their specific receptor molecules initiates a broad and varied array of signals that induce cellular antiviral states, modulate inflammatory responses, inhibit or stimulate cell growth, produce or inhibit apoptosis, and affect many immune mechanisms.

The following are outlines of "IL-10 Family Ligand Review Page", which briefly introduce each member of IL-10 family ligand. If you want more details, please click here.

• Interleukin-10 • Interleukin-20
• Interleukin-24 (MDA-7) • Interleukin-28 and Interleukin-29
• Interleukin-19 • Interleukin-22
• Interleukin-26 (AK155)