The pleiotropic activities of IL-10 family members are mediated by specific cell surface receptor complexes that each consist of an R1 chain and an R2 chain, both being members of the class II cytokine receptor family (CRF2).
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Below are IL-10 receptor family members, and its cognate ligands are written on the right side.
|CD219 / IL10RA||IL10/IL-10/Interleukin-10|
|IL10RB / IL-10RB||IL10/IL-10/Interleukin-10, IL-26/AK155, IL-28A/IFN-lambda 2, IL-28B/IFN-lambda 3|
|IL20RA/IL-20RA||IL19 / Interleukin-19, interleukin-20, IL-24/MDA-7, IL-26/AK155|
|IL20RB||IL19 / Interleukin-19, interleukin-20, IL-24/MDA-7|
|IL-22R / IL22RA1||IL22 / Interleukin 22|
|IL-22BP/IL-22RA2||IL22 / Interleukin 22|
|IL-28 R alpha/IFN-lambda R1||IL-29/IFN-lambda 1, IL-28A/IFN-lambda 2, IL-28B/IFN-lambda 3|
IL-10 receptor family belongs to the class II cytokine receptor family (CRF2), due to the presence of two particular disulfide bridges and the absence of the so-called "WSXWS" motif in the C-terminal part of the extracellular domain. The cognate ligands for the class II cytokine receptors are thus referred to as the class II cytokines.
The following are outlines of "IL-10 Receptor Family Review Page", which briefly introduce each member of IL-10 family ligand. If you want more details, please click here.
|• IL-10 Receptor Complex||• IL-22 Receptor Complex|
|• IL-20 Receptor Complex||• IFN lambda Receptor 1/IL-28R1|