Each IL-12 family member is composed of alpha-subunit with a helical structure similar to type 1 cytokines like IL-6 and a beta-subunit structurally related to the extracellular regions of Type 1 cytokine receptors (e.g. soluble IL-6 receptor).
IL-12 family cytokines are important mediators of immune-mediated inflammatory diseases such as psoriasis, multiple sclerosis, rheumatoid arthritis, and Crohn's disease.
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Type I cytokines include the IL-6 and IL-12 families, which consist of structurally related four-helix bundle proteins. Unlike members of the IL-6 family, which are secreted as single-subunit monomers, IL-12 family members form heterodimeric complexes.
| Ligand | Subunits | Receptor | Function |
| IL-12 | p35+p40 | IL12RB1(CD212), IL12RB2 | Th1 differentiation; Th2 inhibition |
| IL-23 | p19+p40 | IL12RB1(CD212), IL23R / IL23 Receptor | Th17 differentiation |
| IL-27 | p28+EBI3 | IL12RB1(CD212), WSX-1/IL-27R | Th1 differentiation Suppression of Th17; differentiation Stimulation of Tr1 cells |
| IL-35 | p35+EBI3 | IL12RB2, IL6ST/gp130/CD130, WSX-1/IL-27R | Treg proliferation Suppression of Th1 and Th17 cell development |
The IL-12 family of cytokines consist of IL-12 (IL-12p35/IL-12p40), IL-23 (IL-23p19/IL-12p40), IL-27 (IL-27p28/Ebi3) and IL-35 (IL-12p35/Ebi3) and has emerged as important regulators of host immunity.
The following are outlines of "IL-12 Family Ligand Review Page", which briefly introduce each member of IL-12 family ligand. If you want more details, please click here.
| • IL-12 Receptor | • IL-27 Receptor |
| • IL-23 Receptor | • IL-35 Receptor |
